BCS1L and MRPS12

Number of citations: 0 (PubMedID 32877691)
Data Source: BioGRID (proximity labelling technology)

		BCS1L	MRPS12
Name		BCS1 ubiquinol-cytochrome c reductase complex chaperone	mitochondrial ribosomal protein S12
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Small Ribosomal Subunit Ribosome Small Ribosomal Subunit Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Mitochondrion Organization Protein Insertion Into Mitochondrial Inner Membrane From Matrix Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Cytochrome C Oxidase Assembly Mitochondrial Respiratory Chain Complex III Assembly	Translation Mitochondrial Translation
Pathways		Mitochondrial protein import Complex III assembly	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Diseases		Bjornstad syndrome Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	None
GWAS		Male-pattern baldness ( 28196072 )	No GWAS studies recorded
Novel Interactors		11 novel interactors: AOX1 ARHGAP18 CD28 CLK1 CTLA4 MRPS12 ORC2 RP9 RPE SLC29A1 WDFY1	1 novel interactors: BCS1L
Interacting Genes		3 interacting genes: DDX24 DNAJA1 MTDH	6 interacting genes: CRMP1 ERG28 LRIF1 SPINK7 UBC UNC119
Entrez ID		617	6183
HPRD ID		04708	04316
Ensembl ID		ENSG00000074582	ENSG00000128626
Uniprot IDs		A0A024R445 A8JZZ8 Q9Y276	O15235
PDB IDs		Not available	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
GO Terms Enriched among Interactors		Protein Complex Involved In Cell Adhesion	None