BRD2 and CLCN2

		BRD2	CLCN2
Description		bromodomain containing 2	chloride voltage-gated channel 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck	Plasma Membrane Membrane Basolateral Plasma Membrane Axon Dendrite Dendritic Spine Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Cell Projection Axon Initial Segment Perikaryon Myelin Sheath Synapse Postsynaptic Membrane Astrocyte End-foot
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Binding Protein-macromolecule Adaptor Activity Histone Binding Histone H4K12ac Reader Activity Histone H4K5ac Reader Activity Histone H3K14ac Reader Activity Acetylation-dependent Protein Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Voltage-gated Monoatomic Anion Channel Activity Chloride Transmembrane Transporter Activity Chloride Channel Regulator Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Neural Tube Closure Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Regulation Of Gene Expression Protein Localization To Chromatin T-helper 17 Cell Lineage Commitment Chromatin Looping Positive Regulation Of T-helper 17 Cell Lineage Commitment	Monoatomic Ion Transport Chloride Transport Phagocytosis, Engulfment Stabilization Of Membrane Potential Lung Development Regulation Of Aldosterone Biosynthetic Process Monoatomic Ion Transmembrane Transport Positive Regulation Of Oligodendrocyte Differentiation Transmembrane Transport Retina Development In Camera-type Eye Regulation Of Resting Membrane Potential Cell Differentiation Involved In Salivary Gland Development Regulation Of Biological Quality Cellular Hypotonic Response Acinar Cell Differentiation Monoatomic Anion Transmembrane Transport Regulation Of Membrane Depolarization During Action Potential Chloride Transmembrane Transport
Pathways		RUNX3 regulates p14-ARF	Stimuli-sensing channels
Drugs			Lubiprostone Cobiprostone
Diseases			Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 28008999) Feeling nervous ( 29500382) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28008999) Ulcerative colitis ( 28008999)	General cognitive ability ( 29844566)
Interacting Genes		8 interacting genes: E2F1 E2F2 H2BC26 H4C16 MECOM PKNOX1 SPOP TOP1	4 interacting genes: ATXN1 FHL3 PPP1CA UBQLN1
Entrez ID		6046	1181
HPRD ID		03326	02782
Ensembl ID		ENSG00000204256	ENSG00000114859
Uniprot IDs		A0A1U9X7A8 E9PIQ3 P25440 X5CF57	P51788
PDB IDs		1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH 4J1P 4MR5 4MR6 4QEU 4QEV 4QEW 4UYF 4UYG 4UYH 5BT5 5DFB 5DFC 5DFD 5DW1 5EK9 5HEL 5HEM 5HEN 5HFQ 5IBN 5IG6 5N2L 5O38 5O39 5O3A 5O3B 5O3C 5O3D 5O3E 5O3F 5O3G 5O3H 5O3I 5S9O 5U5S 5U6V 5UEW 5XHE 5XHK 6CUI 6DB0 6DBC 6DDI 6DDJ 6E6J 6FFE 6FFF 6FFG 6I80 6I81 6JKE 6K04 6K05 6MO7 6MO8 6MO9 6MOA 6ONY 6SWO 6SWP 6TQ1 6TQ2 6U61 6U71 6U8H 6ULQ 6ULT 6VIY 6WWB 6YTM 6Z7F 6Z8P 6ZB0 6ZB1 6ZB2 7DPN 7DPO 7ENV 7ENZ 7EO5 7JX7 7L6D 7L9G 7L9J 7L9K 7LAK 7NPY 7NPZ 7NQ0 7NQ1 7NQ2 7NQ3 7NQ5 7NQ7 7NQ8 7NQ9 7NQI 7NQJ 7OE4 7OE5 7OE6 7OE8 7OE9 7OEP 7OER 7OES 7OET 7OGY 7Q5O 7USG 7USH 7USI 7UU0 7VRH 7VRI 7VRK 7VRM 7VRO 7VRQ 7VRZ 7VS0 7VS1 7VSF 7WLN 7WMQ 7WMU 7WN5 7WNA 7WNI 8B5G 8B5H 8B5I 8B5J 8CV7 8DNQ 8PX2 8PX8 8SB6 8WYG 8Z69 9FBX	7XF5 7XJA 8GQU 8TA2 8TA3 8TA4 8TA5 8TA6
Enriched GO Terms of Interacting Partners?		Lens Fiber Cell Apoptotic Process Rb-E2F Complex DNA Binding	RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Postsynapse Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Histone H4K5ac Reader Activity Histone H3K14ac Reader Activity Histone H4K12ac Reader Activity Acetylation-dependent Protein Binding Positive Regulation Of T-helper 17 Cell Lineage Commitment Poly(G) Binding POZ Domain Binding Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
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