RFC2 and EIF4H

		RFC2	EIF4H
Description		replication factor C subunit 2	eukaryotic translation initiation factor 4H
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex	Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding Cadherin Binding
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Sexual Reproduction Developmental Growth Eukaryotic Translation Initiation Factor 4F Complex Assembly
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: CEBPA HGS KLHL20 PCNA PRKAR1A PSMA1 RAD17 RAD18 RFC1 RFC4 RFC5 SUMO2 YOD1 ZIC1	8 interacting genes: C11orf68 CEBPA DDIT4L DLG3 FBXO17 LNX1 PICK1 SPG21
Entrez ID		5982	7458
HPRD ID		02675	11940
Ensembl ID		ENSG00000049541	ENSG00000106682
Uniprot IDs		A0A087WVY3 P35250 Q75MT5	Q15056
PDB IDs		6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?		DNA Clamp Loader Activity DNA Replication Factor C Complex Positive Regulation Of DNA-directed DNA Polymerase Activity Elg1 RFC-like Complex DNA Repair Macromolecule Metabolic Process DNA Replication Positive Regulation Of DNA Biosynthetic Process DNA-templated DNA Replication Ctf18 RFC-like Complex Cellular Response To Stress DNA Metabolic Process DNA Damage Response Protein Domain Specific Binding Regulation Of DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Ubiquitin Protein Ligase Binding Single-stranded DNA Helicase Activity DNA Strand Elongation Chromosome Ubiquitin-like Protein Ligase Binding Replication Fork Nucleoplasm Regulation Of Primary Metabolic Process Postreplication Repair Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process PCNA Complex Replisome Rad17 RFC-like Complex Type II Interferon Binding Rad6-Rad18 Complex Animal Organ Regeneration DNA Binding Regulation Of Catalytic Activity Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Vitamin B2 C/EBP Complex Damaged DNA Binding PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Positive Regulation Of DNA Metabolic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
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