RCN1 and RAG2

		RCN1	RAG2
Description		reticulocalbin 1	recombination activating 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Nucleus Nucleoplasm DNA Recombinase Complex
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Sequence-specific DNA Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate Binding Histone H3K4me3 Reader Activity
	Biological Process	In Utero Embryonic Development Camera-type Eye Development	Mature B Cell Differentiation Involved In Immune Response B Cell Lineage Commitment Pre-B Cell Allelic Exclusion B Cell Homeostatic Proliferation T Cell Lineage Commitment DNA Recombination Chromatin Organization B Cell Differentiation T Cell Differentiation T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation In Thymus V(D)J Recombination Organ Growth Defense Response To Bacterium Positive Regulation Of Organ Growth DN2 Thymocyte Differentiation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Apolipoprotein B levels ( 32203549) Basophil count ( 32888494) Blood protein levels ( 30072576) Body mass index ( 28371326) General factor of neuroticism ( 30867560) Major depressive disorder ( 27479909) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Refractive error ( 32231278)	Rheumatoid arthritis ( 24390342)
Interacting Genes		19 interacting genes: ASB8 ASPH ATPAF2 ATXN1 CETN3 DCAF11 EFHC1 ENKD1 FAM110A GADD45G LMO1 LMO2 LMO3 LMO4 MYO15B PTEN SGTA SGTB ZNF410	4 interacting genes: FOXP1 IPO5 RAG1 SKP2
Entrez ID		5954	5897
HPRD ID		04111	08913
Ensembl ID		ENSG00000049449	ENSG00000175097
Uniprot IDs		Q15293 V9HW95	P55895
PDB IDs			8T4R
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Organ Growth Positive Regulation Of Metabolic Process Microtubule-based Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Targeting To ER Positive Regulation Of Macromolecule Metabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Biosynthetic Process Establishment Of Mitotic Spindle Orientation Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Establishment Of Mitotic Spindle Localization Negative Regulation Of Synaptic Vesicle Clustering Spindle Organization Spindle Pole Transcription Coregulator Binding	Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Lymphocyte Apoptotic Process Double-stranded DNA Endonuclease Activity Negative Regulation Of Leukocyte Apoptotic Process DNA Recombinase Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-21 Production
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