BCAT1 and C17orf75

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BCAT1	C17orf75
Description		branched chain amino acid transaminase 1	chromosome 17 open reading frame 75
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle
	Molecular Function	Catalytic Activity Branched-chain-amino-acid Transaminase Activity Protein Binding Transaminase Activity Transferase Activity L-leucine-2-oxoglutarate Transaminase Activity L-valine-2-oxoglutarate Transaminase Activity L-isoleucine-2-oxoglutarate Transaminase Activity	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Lipid Metabolic Process Amino Acid Biosynthetic Process Branched-chain Amino Acid Metabolic Process Branched-chain Amino Acid Biosynthetic Process Branched-chain Amino Acid Catabolic Process	Intracellular Protein Transport Vesicle Tethering To Golgi
Pathways		Branched-chain amino acid catabolism
Drugs		Pyridoxal phosphate Glutamic acid Leucine Valine Isoleucine N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
Diseases
GWAS		Adventurousness ( 30643258) Atrial fibrillation ( 29892015) Body size at age 10 ( 32376654) Breast cancer ( 31757997) Calcium levels ( 25972035) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Major depressive disorder x sex interaction ( 34099189) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) PR interval ( 30679814 32439900) Pulse pressure ( 30224653) Response to statin therapy ( 20339536) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Uterine fibroid size (maximum volume) ( 30196971)
Interacting Genes		8 interacting genes: C17orf75 CEBPA ENKD1 KDM1A PRMT6 SMAD5 TRIM55 TRIM63	5 interacting genes: BCAT1 COPS3 DUSP29 MESD OGT
Entrez ID		586	64149
HPRD ID		00216	11392
Ensembl ID		ENSG00000060982	ENSG00000108666
Uniprot IDs		P54687	Q9HAS0
PDB IDs		2ABJ 2COG 2COI 2COJ 7NTR 7NWA 7NWB 7NWC 7NWE 7NWM 7NXN 7NXO 7NY2 7NY9 7NYA
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Stem Cell Proliferation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Cell Differentiation Response To Vitamin B2 C/EBP Complex Regulation Of Cell Differentiation Negative Regulation Of Fas Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Microtubule Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of RNA Metabolic Process Chromatin Binding Negative Regulation Of DNA-templated Transcription Regulation Of Osteoblast Differentiation CHOP-C/EBP Complex Response To Phenylpropanoid Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Multicellular Organismal Development Positive Regulation Of Developmental Process DNA-binding Transcription Factor Binding Chromatin DNA-binding Transcription Factor Activity White Fat Cell Proliferation Response To Glucocorticoid Response To Corticosteroid Negative Regulation Of RNA Biosynthetic Process Cell Maturation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Developmental Process Fat Cell Proliferation Cartilage Development Regulation Of Fas Signaling Pathway Heteromeric SMAD Protein Complex Anti-Mullerian Hormone Receptor Signaling Pathway Mullerian Duct Regression Osteoblast Fate Commitment Cell Fate Commitment SMAD Protein Complex DEAD/H-box RNA Helicase Binding Asymmetric Neuroblast Division Positive Regulation Of Mesenchymal Stem Cell Differentiation	Branched-chain-amino-acid Transaminase Activity L-leucine-2-oxoglutarate Transaminase Activity L-isoleucine-2-oxoglutarate Transaminase Activity L-valine-2-oxoglutarate Transaminase Activity Branched-chain Amino Acid Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Carbohydrate Homeostasis Non-canonical Inflammasome Complex Assembly Glucose Homeostasis Positive Regulation Of Transcription By Glucose Regulation Of Post-translational Protein Modification Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Localization To Membrane Protein O-acetylglucosaminyltransferase Activity MAP Kinase Phosphatase Activity Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Transcription By Glucose Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering NSL Complex Protein Deneddylation Positive Regulation Of Receptor Clustering
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