TP53INP2 and BECN2

Number of citations: 31 (PubMedID 23954414)
Data Source: BioGRID (two hybrid)

		TP53INP2	BECN2
Name		tumor protein p53 inducible nuclear protein 2	beclin 2
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome Cytosol PML Body Cytoplasmic Vesicle	Phagophore Assembly Site Cytoplasm Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II
	Molecular Function	Protein Binding Ubiquitin Binding	Protein Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol 3-kinase Binding Protein-containing Complex Binding
	Biological Process	Autophagosome Assembly Osteoblast Differentiation Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Autophagy Intracellular Protein Localization Macroautophagy Positive Regulation Of DNA-templated Transcription Negative Regulation Of Protein Localization	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Endosome To Lysosome Transport Receptor Catabolic Process Glucose Homeostasis Late Endosome To Vacuole Transport G Protein-coupled Receptor Catabolic Process
GWAS		Bipolar disorder ( 31043756 ) Colorectal cancer or advanced adenoma ( 30510241 ) Estimated glomerular filtration rate ( 30604766 ) Fish- and plant-related diet ( 32066663 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Urate levels ( 31578528 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: BECN2 GABARAPL2 MAP1LC3A	3 interacting genes: ADRB2 CNR1 TP53INP2
Entrez ID		58476	441925
HPRD ID		15546	Not available
Ensembl ID		ENSG00000078804	ENSG00000196289
Uniprot IDs		Q8IXH6	A8MW95
PDB IDs		7YO9 8T31 8T32 8T33 8T35 8T36 8T4T	5K7B 5K9L 8GT9 8GU7
GO Terms Enriched among Interactors		Cellular Response To Nitrogen Starvation Mitophagy Autophagy Of Mitochondrion Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Cellular Response To Starvation Phosphatidylethanolamine Binding Response To Starvation Cellular Response To Nutrient Levels Autophagy Response To Nutrient Levels Autophagosome Maturation Autophagosome Membrane Autophagosome Organelle Assembly Phospholipid Binding Protein-containing Complex Disassembly G Protein-coupled Receptor Catabolic Process Microtubule Binding Cellular Response To Oxygen-glucose Deprivation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I Cellular Response To Stress Ubiquitin Protein Ligase Binding Response To Iron(II) Ion Catabolic Process Response To Oxygen-glucose Deprivation Autolysosome Organelle Organization Protein Localization To Endoplasmic Reticulum GABA Receptor Binding Cellular Component Assembly Positive Regulation Of ATP-dependent Activity Response To Lead Ion Receptor Catabolic Process Phosphatidylinositol 3-kinase Binding Cellular Response To Copper Ion SMAD Protein Signal Transduction P38MAPK Cascade Phagophore Assembly Site Intra-Golgi Vesicle-mediated Transport Regulation Of ATP-dependent Activity Response To Iron Ion Response To Copper Ion Response To Stress Late Endosome To Vacuole Transport Cytoplasmic Vesicle Beta-tubulin Binding	Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Anatomical Structure Homeostasis Tissue Homeostasis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Homeostatic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Cannabinoid Receptor Activity Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Response To Psychosocial Stress Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Autophagosome Maturation Heat Generation G Protein-coupled Receptor Activity Adrenergic Receptor Activity Diet Induced Thermogenesis Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Multicellular Organism Growth Multicellular Organismal-level Homeostasis Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Neuron Projection Fasciculation Axonal Fasciculation Adaptive Thermogenesis Bone Resorption Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Brown Fat Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential G Protein-coupled Receptor Signaling Pathway Temperature Homeostasis Positive Regulation Of Protein-containing Complex Disassembly Response To Cold Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of CAMP/PKA Signal Transduction Potassium Channel Regulator Activity