MS4A7 and DRAM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MS4A7	DRAM1
Description		membrane spanning 4-domains A7	DNA damage regulated autophagy modulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Plasma Membrane Membrane	Cytoplasm Lysosome Lysosomal Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway	Autophagy Apoptotic Process Regulation Of Autophagy Cellular Response To Oxygen-glucose Deprivation
Pathways
Drugs
Diseases
GWAS		Iron status biomarkers (ferritin levels) ( 33536631) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)	Appendicular lean mass ( 33097823) Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 30823506) Shigella-associated diarrhea ( 33649051) Systemic lupus erythematosus ( 23273568 33272962)
Interacting Genes		10 interacting genes: CD72 DRAM1 EMP1 HMGCL IGFBP5 ITGB2 LAT PLN PMP22 SLC35F6	11 interacting genes: APP C1orf21 CD164L2 CLRN1 CREB3 EPS15 EVI2B GPR42 LRRC4C MS4A7 TIMMDC1
Entrez ID		58475	55332
HPRD ID		07579	07743
Ensembl ID		ENSG00000166927	ENSG00000136048
Uniprot IDs		Q9GZW8	Q8N682
PDB IDs
Enriched GO Terms of Interacting Partners?		Bleb Assembly Apoptotic Process Hydroxymethylglutaryl-CoA Lyase Activity Oxo-acid-lyase Activity Negative Regulation Of Skeletal Muscle Hypertrophy Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process TCR Signalosome Cell Death Programmed Cell Death Insulin-like Growth Factor Binding Protein Complex ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin-mediated Signaling Pathway Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Regulation Of Monocyte Chemotaxis Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Deacetylase Activity Myeloid Cell Development Membrane Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Mononuclear Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Clathrin-coated Pit Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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