RAP2C and RAB40B

Number of citations of the paper that reports this interaction (PubMedID 35293963)
87

Data Source:
BioGRID (pull down)

		RAP2C	RAB40B
Description		RAP2C, member of RAS oncogene family	RAB40B, member RAS oncogene family
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Endomembrane System Membrane Cytoplasmic Vesicle Membrane Cell-cell Contact Zone Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle	Ruffle Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Lamellipodium Lamellipodium Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Migration Rap Protein Signal Transduction Positive Regulation Of DNA-templated Transcription Regulation Of Protein Tyrosine Kinase Activity Establishment Of Endothelial Intestinal Barrier	Exocytosis Protein Ubiquitination Positive Regulation Of Cell Migration Negative Regulation Of Actin Filament Bundle Assembly Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Lamellipodium Organization Cellular Detoxification
Pathways		Neutrophil degranulation	RAB geranylgeranylation
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031) Uterine fibroids ( 31649266)	Colorectal cancer or advanced adenoma ( 30510241)
Interacting Genes		2 interacting genes: ADRB2 RAB40B	10 interacting genes: ANKRD27 APP CRYAA EFEMP2 FHIT FHL3 RAP2A RAP2B RAP2C WFDC1
Entrez ID		57826	10966
HPRD ID		06706	11472
Ensembl ID		ENSG00000123728	ENSG00000141542
Uniprot IDs		A0A087X2C3 Q9Y3L5	Q12829
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity Positive Regulation Of Autophagosome Maturation Heat Generation Adrenergic Receptor Activity Diet Induced Thermogenesis Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Endosome Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Adaptive Thermogenesis Lamellipodium Membrane Bone Resorption Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Brown Fat Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of CAMP/PKA Signal Transduction Potassium Channel Regulator Activity Temperature Homeostasis Glutamate Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Disassembly Vesicle-mediated Transport Ligand-gated Ion Channel Signaling Pathway Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure Response To Cold Negative Regulation Of Blood Pressure Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Organelle Organization Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lamellipodium Organization Smooth Muscle Contraction Vasodilation	Rap Protein Signal Transduction Bounding Membrane Of Organelle Recycling Endosome Cytoplasmic Vesicle Membrane GDP Binding Endomembrane System G Protein Activity Recycling Endosome Membrane Endosome Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Tyrosine Kinase Activity Cell-cell Contact Zone Establishment Of Endothelial Barrier Endothelial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenylylsulfatase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Diadenosine Triphosphate Catabolic Process Regulation Of Dendrite Morphogenesis Small GTPase-mediated Signal Transduction Tertiary Granule Membrane Positive Regulation Of Smooth Muscle Cell-matrix Adhesion GTPase Activity Negative Regulation Of Cell Migration Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Development Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Import GTP Binding Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Negative Regulation Of SNARE Complex Assembly PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
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