HAMP and SLC40A1

Number of citations of the paper that reports this interaction (PMID 15514116)
532

Data Source:
HPRD (in vivo)

		HAMP	SLC40A1
Gene Name		hepcidin antimicrobial peptide	solute carrier family 40 (iron-regulated transporter), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Apical Cortex	Intracellular Cytoplasm Multivesicular Body Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Hormone Activity	Iron Ion Transmembrane Transporter Activity Protein Binding
	Biological Process	Cellular Iron Ion Homeostasis Immune Response Killing Of Cells Of Other Organism Defense Response To Bacterium Defense Response To Fungus	Lymphocyte Homeostasis Endothelium Development Cellular Iron Ion Homeostasis Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Iron Ion Transmembrane Transport Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transmembrane Transport Spleen Trabecula Formation Multicellular Organismal Iron Ion Homeostasis
Pathways			Metal ion SLC transporters Iron uptake and transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CKAP4 SLC40A1 VKORC1	2 interactors: GOLM1 HAMP
Entrez ID		57817	30061
HPRD ID		05925	05229
Ensembl ID			ENSG00000138449
Uniprot IDs		P81172	Q9NP59
PDB IDs		1M4E 1M4F 2KEF 3H0T
Enriched GO Terms of Interacting Partners?		Spleen Trabecula Formation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Vitamin K Metabolic Process Cellular Response To Iron Ion Peptidyl-glutamic Acid Carboxylation Iron Ion Transmembrane Transport Multicellular Organismal Iron Ion Homeostasis Response To Iron Ion Quinone Metabolic Process Drug Metabolic Process Spleen Development Trabecula Morphogenesis Lymphocyte Homeostasis Iron Ion Transport Cellular Ketone Metabolic Process Cellular Iron Ion Homeostasis Leukocyte Homeostasis Endothelium Development Vitamin Metabolic Process Iron Ion Homeostasis Cellular Response To Metal Ion	Killing Of Cells Of Other Organism Defense Response To Fungus Response To Fungus Cellular Iron Ion Homeostasis Iron Ion Homeostasis Nucleus Organization Transition Metal Ion Homeostasis
Tagcloud ?		anchored bacterial balancing bound communication completely cytosolic delimited diverse domains foreign hamps input intersection language localized machinery membrane modules operate organization output predominantly sensor sensors signal summarized transducers universal	adrenal alternatively anaemia autosomal chelating cirrhosis cousins deferasirox deferoxamin develops export extremely ferritin ferroportin gland hemochromatosis hepcidin histologically hyperferritinaemia mother overload phlebotomies pituitary saturation spleen synonym t2 transferrin weighting
Tagcloud (Difference) ?		anchored bacterial balancing bound communication completely cytosolic delimited diverse domains foreign hamps input intersection language localized machinery membrane modules operate organization output predominantly sensor sensors signal summarized transducers universal	adrenal alternatively anaemia autosomal chelating cirrhosis cousins deferasirox deferoxamin develops export extremely ferritin ferroportin gland hemochromatosis hepcidin histologically hyperferritinaemia mother overload phlebotomies pituitary saturation spleen synonym t2 transferrin weighting
Tagcloud (Intersection) ?