HAMP and SLC40A1

Number of citations of the paper that reports this interaction (PubMedID 15514116)
0

Data Source:
HPRD (in vivo)

		HAMP	SLC40A1
Description		hepcidin antimicrobial peptide	solute carrier family 40 member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Membrane Basolateral Plasma Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Iron Ion Transmembrane Transporter Inhibitor Activity Transporter Regulator Activity	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Internalization Intracellular Iron Ion Homeostasis Immune Response Signal Transduction Response To Iron Ion Killing Of Cells Of Another Organism Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Iron Ion Transmembrane Transport Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Monoatomic Cation Homeostasis Multicellular Organismal-level Iron Ion Homeostasis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Inorganic Ion Homeostasis Positive Regulation Of Protein Polyubiquitination Iron Ion Export Across Plasma Membrane Negative Regulation Of Iron Export Across Plasma Membrane Negative Regulation Of Intestinal Absorption Positive Regulation Of Receptor Catabolic Process	Lymphocyte Homeostasis Endothelium Development Transcription By RNA Polymerase II Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Apoptotic Process Iron Ion Transmembrane Transport Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Establishment Of Localization In Cell Transmembrane Transport Spleen Trabecula Formation Multicellular Organismal-level Iron Ion Homeostasis Iron Ion Export Across Plasma Membrane
Pathways			Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport
Drugs
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)	Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Irritable bowel syndrome ( 29673008) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 32888494)	Bone fracture in osteoporosis ( 28580392) Hematocrit ( 32888494) Iron status biomarkers (ferritin levels) ( 25352340 33536631) Iron status biomarkers (total iron binding capacity) ( 28334935 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935) Liver iron content ( 34128465) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 32888494) Restless legs syndrome ( 33239738)
Interacting Genes		4 interacting genes: CKAP4 GLP1R SLC40A1 VKORC1	3 interacting genes: GOLM1 HAMP SLC22A2
Entrez ID		57817	30061
HPRD ID		05925	05229
Ensembl ID		ENSG00000105697	ENSG00000138449
Uniprot IDs		P81172	Q9NP59
PDB IDs		1M4E 1M4F 2KEF 3H0T 4QAE 6WBV	6W4S 6WBV 8BZY 8C02 8C03 8DL6 8DL7 8DL8
Enriched GO Terms of Interacting Partners?		Peptide Hormone Binding Glucagon-like Peptide 1 Receptor Activity Spleen Trabecula Formation Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Glucagon Receptor Activity Iron Ion Export Across Plasma Membrane Response To Psychosocial Stress Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Activation Of Adenylate Cyclase Activity Lamellar Body Endoplasmic Reticulum Lumen Ferrous Iron Transmembrane Transporter Activity Endothelium Development Iron Ion Transmembrane Transporter Activity Cytoplasmic Exosome (RNase Complex) Exoribonuclease Complex RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Iron Ion Transmembrane Transport RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Response To Glucagon Positive Regulation Of Cyclase Activity SnRNA 3'-end Processing Multicellular Organismal-level Iron Ion Homeostasis DNA Modification Intracellular Protein Transmembrane Transport 3'-5'-RNA Exonuclease Activity Positive Regulation Of Coagulation Positive Regulation Of Blood Pressure	Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Export Across Plasma Membrane Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Amine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Peptidyl-lysine N6-acetylation L-cysteine-S-conjugate N-acetyltransferase Activity Negative Regulation Of Iron Export Across Plasma Membrane Negative Regulation Of Iron Ion Transmembrane Transport Iron Ion Transmembrane Transporter Inhibitor Activity Negative Regulation Of Intestinal Absorption Negative Regulation Of Iron Ion Transport Iron Ion Export Across Plasma Membrane Transporter Regulator Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Iron Ion Transport Toxin Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Choline Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Norepinephrine Transport Histamine Transport L-arginine Transmembrane Transporter Activity Internal Peptidyl-lysine Acetylation Positive Regulation Of Receptor Catabolic Process Organic Cation Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity L-arginine Transmembrane Transport Amine Transport Catecholamine Uptake Dopamine Uptake Internal Protein Amino Acid Acetylation Azole Transmembrane Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?