ANKRA2 and RFX5

Number of citations of the paper that reports this interaction (PMID 22649097)
2

Data Source:
BioGRID (unspecified method)

		ANKRA2	RFX5
Gene Name		ankyrin repeat, family A (RFXANK-like), 2	regulatory factor X, 5 (influences HLA class II expression)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Membrane	Nucleus
	Molecular Function	Transcription Cofactor Activity Low-density Lipoprotein Particle Binding Histone Deacetylase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Biological_process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ABL1 APP HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX5	5 interactors: ANKRA2 CIITA HDAC2 RFXANK RFXAP
Entrez ID		57763	5993
HPRD ID		12044	03517
Ensembl ID		ENSG00000164331	ENSG00000143390
Uniprot IDs		Q9H9E1	B7Z848 P48382
PDB IDs		3SO8 3V2O 3V2X 3V31 4LG6	2KW3 3V30
Enriched GO Terms of Interacting Partners?		Regulation Of Skeletal Muscle Fiber Development B Cell Differentiation Cell Activation Histone H4 Deacetylation Regulation Of Muscle Cell Differentiation Histone H3 Deacetylation B Cell Activation Histone H3-K9 Modification Regulation Of Myotube Differentiation Collateral Sprouting Regulation Of Skeletal Muscle Tissue Development Lymphocyte Differentiation Histone Deacetylation Protein Deacetylation Peptidyl-lysine Deacetylation Regulation Of Striated Muscle Cell Differentiation Response To Stress Leukocyte Differentiation Signal Transduction Negative Regulation Of Myotube Differentiation Lymphocyte Activation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Coagulation Regulation Of Striated Muscle Tissue Development Signaling Hemostasis Cell Communication Regulation Of Sprouting Angiogenesis Notch Signaling Pathway Regulation Of Protein Binding Cellular Response To Organonitrogen Compound Negative Regulation Of Striated Muscle Cell Differentiation Leukocyte Activation Organ Development Osteoblast Development Regulation Of Cellular Senescence Regulation Of Body Fluid Levels Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Wound Healing Cellular Response To Stimulus Cellular Response To Insulin Stimulus Hemopoiesis Regulation Of Angiogenesis Defense Response Response To Wounding Immune System Development Regulation Of Binding Negative Regulation Of Muscle Cell Differentiation Negative Regulation Of Osteoblast Differentiation	Regulation Of Collagen Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Maintenance Of Chromatin Silencing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of MHC Class II Biosynthetic Process Fungiform Papilla Formation Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Fungiform Papilla Morphogenesis Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Regulation Of Sarcomere Organization Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Positive Regulation Of Oligodendrocyte Differentiation Tongue Morphogenesis Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Tissue Development Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Histone H3 Deacetylation Negative Regulation Of Organ Growth Tongue Development Positive Regulation Of Glial Cell Differentiation Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Regulation Of Oligodendrocyte Differentiation Regulation Of Cardiac Muscle Cell Proliferation RNA Biosynthetic Process Negative Regulation Of Striated Muscle Tissue Development Response To Cocaine
Tagcloud ?		ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 rfxank sequester serving switch tumbler uncharacterized uncover	bind box boxes conserved contributions cus dictate dra effectors entire flanking functionally herpes heterodimer histocompatibility homodimer p36 plasmid proper rfx1 simplex spacing stabilized upstream vp16 x2 y
Tagcloud (Difference) ?		ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfxank sequester serving switch tumbler uncharacterized uncover	bind box boxes conserved contributions cus dictate dra effectors entire flanking functionally herpes heterodimer histocompatibility homodimer p36 plasmid proper rfx1 simplex spacing stabilized upstream vp16 x2 y
Tagcloud (Intersection) ?		rfx5