TNRC6C and AGO4

Number of citations of the paper that reports this interaction (PMID 19383768)
46

Data Source:
BioGRID (pull down)

		TNRC6C	AGO4
Gene Name		trinucleotide repeat containing 6C	argonaute RISC catalytic component 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasmic MRNA Processing Body Cytosol Membrane RISC Complex Micro-ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding	Protein Binding MiRNA Binding
	Biological Process	Endoderm Formation Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Posttranscriptional Gene Silencing Embryonic Hemopoiesis Gene Silencing By MiRNA Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Gene Silencing By MiRNA Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	MRNA Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Posttranscriptional Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 MicroRNA (miRNA) biogenesis Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Small interfering RNA (siRNA) biogenesis Adaptive Immune System
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		1 interactors: AGO4	4 interactors: APP TNRC6A TNRC6B TNRC6C
Entrez ID		57690	192670
HPRD ID		10026	09559
Ensembl ID		ENSG00000078687	ENSG00000134698
Uniprot IDs		G3XAB8 Q9HCJ0	Q9HCK5
PDB IDs		2DKL 2X04 3KTP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Gene Silencing By MiRNA Posttranscriptional Gene Silencing Gene Silencing By RNA Negative Regulation Of Translation Gene Silencing Phosphatidylinositol-mediated Signaling Notch Signaling Pathway MRNA Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway RNA Catabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Gene Expression, Epigenetic Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Translation	Notch Signaling Pathway Posttranscriptional Gene Silencing Regulation Of Translation Gene Silencing By RNA Posttranscriptional Regulation Of Gene Expression Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Phosphatidylinositol-mediated Signaling Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Regulation Of Gene Expression, Epigenetic Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Fc Receptor Signaling Pathway Immune Response Defense Response Gene Silencing By MiRNA Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Processing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Response To Stress Gene Expression Collateral Sprouting In Absence Of Injury Regulation Of Immune System Process Negative Regulation Of Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition
Tagcloud ?		calpain capn10 carcinoma cdna clinicopathological clinocopathologcial correction differentially esophageal gaec1 greatest knocking kyse150 microarray microarrays mts normalized oncogene parental prominently psilencer rnai squamous transfected transfecting trinucleotide u133 vector	absent ago6 arabidopsis argonaute combinations consistently directed displays foci genomewide immunofluorescence localizes negligible nucleoplasm occupancy perinucleolar physically pol polymerases rddm redundancy redundant rnas scaffold sequentially spatially subnuclear unexpectedly
Tagcloud (Difference) ?		calpain capn10 carcinoma cdna clinicopathological clinocopathologcial correction differentially esophageal gaec1 greatest knocking kyse150 microarray microarrays mts normalized oncogene parental prominently psilencer rnai squamous transfected transfecting trinucleotide u133 vector	absent ago6 arabidopsis argonaute combinations consistently directed displays foci genomewide immunofluorescence localizes negligible nucleoplasm occupancy perinucleolar physically pol polymerases rddm redundancy redundant rnas scaffold sequentially spatially subnuclear unexpectedly
Tagcloud (Intersection) ?