AGO4 and TNRC6B

Number of citations of the paper that reports this interaction (PMID 19383768)
46

Data Source:
BioGRID (pull down)

		AGO4	TNRC6B
Gene Name		argonaute RISC catalytic component 4	trinucleotide repeat containing 6B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytosol Membrane RISC Complex Micro-ribonucleoprotein Complex	Cytoplasmic MRNA Processing Body Cytosol
	Molecular Function	Protein Binding MiRNA Binding	Nucleotide Binding Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Posttranscriptional Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Regulation Of Translation Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Posttranscriptional Gene Silencing Gene Silencing By RNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 MicroRNA (miRNA) biogenesis Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Small interfering RNA (siRNA) biogenesis Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Height ( 19570815) Prostate cancer ( 23065704 19117981) Prostate cancer (gene x gene interaction) ( 22219177) Uterine fibroids ( 21460842)
Protein-Protein Interactions		4 interactors: APP TNRC6A TNRC6B TNRC6C	2 interactors: AGO4 UBQLN4
Entrez ID		192670	23112
HPRD ID		09559	10021
Ensembl ID		ENSG00000134698	ENSG00000100354
Uniprot IDs		Q9HCK5	Q9UPQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Posttranscriptional Gene Silencing Regulation Of Translation Gene Silencing By RNA Posttranscriptional Regulation Of Gene Expression Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Phosphatidylinositol-mediated Signaling Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Regulation Of Gene Expression, Epigenetic Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Fc Receptor Signaling Pathway Immune Response Defense Response Gene Silencing By MiRNA Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Processing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Response To Stress Gene Expression Collateral Sprouting In Absence Of Injury Regulation Of Immune System Process Negative Regulation Of Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition	Negative Regulation Of Translation Involved In Gene Silencing By MiRNA
Tagcloud ?		absent ago6 arabidopsis argonaute combinations consistently directed displays foci genomewide immunofluorescence localizes negligible nucleoplasm occupancy perinucleolar physically pol polymerases rddm redundancy redundant rnas scaffold sequentially spatially subnuclear unexpectedly
Tagcloud (Difference) ?		absent ago6 arabidopsis argonaute combinations consistently directed displays foci genomewide immunofluorescence localizes negligible nucleoplasm occupancy perinucleolar physically pol polymerases rddm redundancy redundant rnas scaffold sequentially spatially subnuclear unexpectedly
Tagcloud (Intersection) ?