GRAMD1A and TLR7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GRAMD1A	TLR7
Gene Name		GRAM domain containing 1A	toll-like receptor 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Golgi Membrane Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Phagosome Endolysosome Membrane Receptor Complex
	Molecular Function		Double-stranded RNA Binding Single-stranded RNA Binding Transmembrane Signaling Receptor Activity Drug Binding SiRNA Binding
	Biological Process		Microglial Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Phosphorylation Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Inflammatory Response Defense Response To Virus Cellular Response To Mechanical Stimulus
Pathways			Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades Toll Like Receptor 7/8 (TLR7/8) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs			Imiquimod Hydroxychloroquine
Diseases
GWAS			Celiac disease ( 20190752)
Protein-Protein Interactions		2 interactors: GMCL1 TLR7	2 interactors: GRAMD1A MYD88
Entrez ID		57655	51284
HPRD ID		11153	02295
Ensembl ID		ENSG00000089351	ENSG00000196664
Uniprot IDs		J3KR86 M0QZ12 Q96CP6	B2R9N9 Q9NYK1
PDB IDs
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interferon-gamma Biosynthetic Process Regulation Of Interleukin-8 Biosynthetic Process Microglial Cell Activation I-kappaB Phosphorylation Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-beta Production Macrophage Activation Positive Regulation Of Interleukin-8 Production Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of NF-kappaB Import Into Nucleus Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Regulation Of Chemokine Production I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Positive Regulation Of Type I Interferon Production Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Inflammatory Response Regulation Of Interleukin-6 Production Regulation Of Type I Interferon Production Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Toll-like Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Defense Response To Virus Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Protein Localization To Nucleus	Response To Molecule Of Fungal Origin Positive Regulation Of Interleukin-23 Production Establishment Of Endothelial Intestinal Barrier 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Interleukin-17 Production Type I Interferon Biosynthetic Process Positive Regulation Of Chemokine Biosynthetic Process Response To Peptidoglycan Toll Signaling Pathway Type I Interferon Production Cytokine Biosynthetic Process MRNA Stabilization Negative Regulation Of Growth Of Symbiont In Host Establishment Of Endothelial Barrier Cytokine Metabolic Process Lipopolysaccharide-mediated Signaling Pathway Response To Fungus Positive Regulation Of Chemokine Production Endothelial Cell Development Regulation Of MRNA Stability Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of RNA Stability Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Interleukin-6 Production Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Endothelial Cell Differentiation Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Response To Interleukin-1 JNK Cascade Endothelium Development Regulation Of Tumor Necrosis Factor Production Regulation Of Smooth Muscle Cell Proliferation Regulation Of Interleukin-6 Production Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Stress-activated MAPK Cascade
Tagcloud ?			abortion anakinra bacteria constituents cpg cpg1826 decidual depleted embryo etanercept hypomethylated injections intraperitoneal ligands motifs murine neutralizing nk nonobese notably preventing r837 raw264 resorption respond stranded tlr9 toll
Tagcloud (Difference) ?			abortion anakinra bacteria constituents cpg cpg1826 decidual depleted embryo etanercept hypomethylated injections intraperitoneal ligands motifs murine neutralizing nk nonobese notably preventing r837 raw264 resorption respond stranded tlr9 toll
Tagcloud (Intersection) ?