GRAMD1A and TLR7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GRAMD1A	TLR7
Description		GRAM domain containing 1A	toll like receptor 7
Image		No pdb structure
GO Annotations	Cellular Component	Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Organelle Membrane Contact Site Endoplasmic Reticulum-plasma Membrane Contact Site	Golgi Membrane Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Phagosome Endolysosome Membrane Receptor Complex Phagocytic Vesicle
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Cholesterol Transfer Activity	Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding SiRNA Binding Pattern Recognition Receptor Activity
	Biological Process	Lipid Transport Autophagy Intracellular Sterol Transport Cellular Response To Cholesterol	MAPK Cascade Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Response To CGMP Cellular Response To Mechanical Stimulus Defense Response To Other Organism Cellular Response To Virus Endolysosomal Toll-like Receptor Signaling Pathway
Pathways			Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade Regulation of TLR by endogenous ligand Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome Defective regulation of TLR7 by endogenous ligand RSV-host interactions
Drugs			Imiquimod Hydroxychloroquine Isatoribine ANA971 Golotimod RG-7795 Resiquimod Afimetoran
Diseases
GWAS		Cognitive decline (age-related) ( 28078323) Hippocampal volume in Alzheimer's disease dementia ( 29274321)	Celiac disease ( 20190752)
Interacting Genes		4 interacting genes: CCR1 GMCL1 MAL TLR7	3 interacting genes: GRAMD1A MYD88 RNF10
Entrez ID		57655	51284
HPRD ID		11153	02295
Ensembl ID		ENSG00000089351	ENSG00000196664
Uniprot IDs		B3KQF7 B3KUH3 M0QZ12 Q96CP6	B2R9N9 Q9NYK1
PDB IDs			7CYN
Enriched GO Terms of Interacting Partners?		Canonical NF-kappaB Signal Transduction Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Chemokine (C-C Motif) Ligand 5 Binding Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Inflammatory Response Membrane Raft Polarization Toll-like Receptor 8 Signaling Pathway Protein Localization To Paranode Region Of Axon Peptidase Activator Activity Involved In Apoptotic Process Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Signal Transduction Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination SiRNA Binding Early Phagosome Response To CGMP Chemokine Receptor Activity Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Dendritic Cell Migration Positive Regulation Of Cell Communication Dendritic Cell Chemotaxis Monocyte Chemotaxis Inflammatory Response Negative Regulation Of Bone Mineralization C-C Chemokine Binding Regulation Of Inflammatory Response Positive Regulation Of Signaling C-C Chemokine Receptor Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Positive Regulation Of Defense Response Apical Protein Localization Endolysosome Membrane Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-alpha Production Endolysosomal Toll-like Receptor Signaling Pathway Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Biomineral Tissue Development Membrane Raft Organization	TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Toll Signaling Pathway Neutrophil-mediated Killing Of Bacterium Regulation Of Interleukin-23 Production Response To Peptidoglycan Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Toll-like Receptor Binding Interleukin-33-mediated Signaling Pathway Response To Alcohol Cellular Response To Lipid Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Interleukin-23 Production Response To Molecule Of Fungal Origin Interleukin-1 Receptor Binding Neutrophil Activation Involved In Immune Response Extrinsic Component Of Plasma Membrane Microglia Differentiation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Organelle Membrane Contact Site Endoplasmic Reticulum-plasma Membrane Contact Site Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane MyD88-dependent Toll-like Receptor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Cellular Response To Cholesterol Death Receptor Binding Negative Regulation Of Glial Cell Proliferation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Myelination 3'-UTR-mediated MRNA Stabilization Cellular Response To Sterol Neutrophil Mediated Immunity Cellular Response To Lipoprotein Particle Stimulus Regulation Of Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of NLRP3 Inflammasome Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Macrophage Cytokine Production Response To Protozoan Establishment Of Endothelial Barrier Killing By Host Of Symbiont Cells
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