GRAMD1A

Description		GRAM domain containing 1A
Image		No pdb structure
GO Annotations	Cellular Component	Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Organelle Membrane Contact Site Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Cholesterol Transfer Activity
	Biological Process	Lipid Transport Autophagy Intracellular Sterol Transport Cellular Response To Cholesterol
Pathways
Drugs
Diseases
GWAS		Cognitive decline (age-related) ( 28078323) Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		4 interacting genes: CCR1 GMCL1 MAL TLR7
Entrez ID		57655
HPRD ID		11153
Ensembl ID		ENSG00000089351
Uniprot IDs		B3KQF7 B3KUH3 M0QZ12 Q96CP6
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical NF-kappaB Signal Transduction Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Chemokine (C-C Motif) Ligand 5 Binding Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Inflammatory Response Membrane Raft Polarization Toll-like Receptor 8 Signaling Pathway Protein Localization To Paranode Region Of Axon Peptidase Activator Activity Involved In Apoptotic Process Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Signal Transduction Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination SiRNA Binding Early Phagosome Response To CGMP Chemokine Receptor Activity Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Dendritic Cell Migration Positive Regulation Of Cell Communication Dendritic Cell Chemotaxis Monocyte Chemotaxis Inflammatory Response Negative Regulation Of Bone Mineralization C-C Chemokine Binding Regulation Of Inflammatory Response Positive Regulation Of Signaling C-C Chemokine Receptor Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Positive Regulation Of Defense Response Apical Protein Localization Endolysosome Membrane Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-alpha Production Endolysosomal Toll-like Receptor Signaling Pathway Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Biomineral Tissue Development Membrane Raft Organization
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