TSHZ3 and ZNF536

		TSHZ3	ZNF536
Description		teashirt zinc finger homeobox 3	zinc finger protein 536
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane Growth Cone Cell Projection	Nucleus
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding Metal Ion Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Neuron Differentiation Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Chronotype ( 30696823) Cognitive performance ( 19734545) Corneal astigmatism ( 30306274) Diastolic blood pressure ( 27841878) Falling risk ( 32999390) FEV1 ( 30804560) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Lung function (FEV1/FVC) ( 30061609 30804560) Peak expiratory flow ( 30804560) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Post bronchodilator FEV1 in COPD ( 26634245) Refractive error ( 32231278) Systemising ( 31508503) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adult body size ( 32376654) Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Age-related hearing impairment ( 24939585) Atorvastatin-induced myopathy ( 31220337) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Chin dimples ( 27182965) Chronotype ( 30696823) Falling risk ( 32999390) General risk tolerance (MTAG) ( 30643258) High density lipoprotein cholesterol levels ( 34074324) Major depressive disorder ( 27479909) Myocardial infarction in hypertension (calcium channel blocker interaction) ( 26516778) Myopia (pathological) ( 23049088) Obesity-related traits ( 23251661) Remission after SSRI treatment in major depression ( 30034349) Schizophrenia ( 29483656 30285260 28991256 25056061) Select biomarker traits ( 17903293) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 27195708)
Interacting Genes		30 interacting genes: ANKRA2 APBB1 APEX2 CCHCR1 CEP63 CEP70 COG6 CTBP1 CTBP2 GOLGA2 HSF2BP KASH5 KRT31 KRT40 LRRC73 MAD1L1 MRPL28 MTUS2 PIBF1 RINT1 ROPN1 SPAG5 TAX1BP1 TEPSIN TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TSC1	1 interacting genes: GGA2
Entrez ID		57616	9745
HPRD ID		18351	15825
Ensembl ID		ENSG00000121297	ENSG00000198597
Uniprot IDs		Q63HK5	A0A994J7Z0 K7EQN6 O15090
PDB IDs		2DMI
Enriched GO Terms of Interacting Partners?		Spindle Organization Spindle Assembly Cytoskeleton Cytoplasm Identical Protein Binding Spindle Pole Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Metaphase Plate Congression DNA Damage Response White Fat Cell Differentiation Microtubule-based Process Viral Genome Replication	Maintenance Of Transcriptional Fidelity During Transcription Elongation By RNA Polymerase II
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