STARD9 and TTBK2

		STARD9	TTBK2
Description		StAR related lipid transfer domain containing 9	tau tubulin kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centriole Cytoskeleton	Extracellular Space Nucleus Cytoplasm Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Base
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding Lipid Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinesin Binding Tau Protein Binding Tau-protein Kinase Activity Microtubule Plus-end Binding Protein Serine Kinase Activity
	Biological Process	Microtubule-based Movement Spindle Assembly	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Signal Transduction Smoothened Signaling Pathway Intracellular Protein Localization Regulation Of Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Cerebellum Development Cerebellar Granular Layer Development Neural Tube Development Cerebellar Granule Cell Precursor Tangential Migration Cell Projection Organization Regulation Of Cell Migration Forebrain Development Protein Localization To Organelle Embryonic Digit Morphogenesis Cilium Assembly Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Non-motile Cilium Assembly Negative Regulation Of Protein Localization Embryonic Brain Development
Pathways			Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Bipolar disorder ( 31043756 34002096) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Glucose homeostasis traits ( 25524916) MGMT methylation in smokers ( 26183928)	Bipolar disorder ( 31043756) Hematocrit ( 32888494) MGMT methylation in smokers ( 26183928)
Interacting Genes		5 interacting genes: CDK5RAP2 HERPUD1 NDUFA7 PPP1CC SVIL	1 interacting genes: KLHL12
Entrez ID		57519	146057
HPRD ID		15442	10288
Ensembl ID		ENSG00000159433	ENSG00000128881
Uniprot IDs		Q9P2P6	Q6IQ55 Q8IWY7
PDB IDs			6U0K 6VRF 7O3B 7Q8Y 7Q8Z 7Q90
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cytoskeleton Organization Cleavage Furrow Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Microtubule Organizing Center Regulation Of Protein Depolymerization Regulation Of Microtubule Polymerization Or Depolymerization Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cytoskeleton Organization Regulation Of Protein-containing Complex Disassembly Lewy Body Core Cerebellar Granular Layer Development Chromosome Segregation Cytoskeleton Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Protein Localization To Microtubule Regulation Of Microtubule Cytoskeleton Organization
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