ZNF490 and TBX21

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZNF490	TBX21
Description		zinc finger protein 490	T-box transcription factor 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Neuronal Cell Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification T-helper 1 Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Virus Positive Regulation Of Gene Expression T Cell Differentiation Negative Regulation Of Interleukin-2 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Lymphocyte Migration Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Generic Transcription Pathway	Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs
Diseases
GWAS		Adult body size ( 32376654)	Ankylosing spondylitis ( 23749187) Asthma ( 34103634 31619474 30929738) Asthma (childhood onset) ( 31036433) Autoimmune thyroid disease ( 32581359) Body mass index ( 28448500 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Diverticular disease ( 30177863) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Multiple sclerosis ( 22190364) Simvastatin-induced myopathy ( 31220337)
Interacting Genes		35 interacting genes: CCDC136 CCNDBP1 CEP70 DTNBP1 FSD2 GLRX3 GOLGA6L9 HAP1 HOXB13 KRT40 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 LMNA LZTR1 LZTS2 MDFI MEOX2 MTUS2 NDEL1 RBMX RNPS1 STX1A TBX21 TEX19 TRAF1 TRIM41 TSGA10 VWC2 ZBTB32 ZC4H2 ZRANB1	3 interacting genes: EXOC5 HOXC11 ZNF490
Entrez ID		57474	30009
HPRD ID		15802	05355
Ensembl ID		ENSG00000188033	ENSG00000073861
Uniprot IDs		Q9ULM2	Q9UL17
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Vesicle Transport Along Microtubule Vesicle Cytoskeletal Trafficking
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