ATP10A and FOXJ1

		ATP10A	FOXJ1
Description		ATPase phospholipid transporting 10A (putative)	forkhead box J1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Phospholipid-translocating ATPase Complex	Chromatin Nucleus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding Phosphatidylcholine Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Phosphatidylcholine Flippase Activity Glycosylceramide Flippase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Lipid Transport Regulation Of Cell Shape Phospholipid Transport Monoatomic Ion Transmembrane Transport Phospholipid Translocation Positive Regulation Of Membrane Tubulation	Negative Regulation Of Transcription By RNA Polymerase II Central Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Brain Development Heart Development Intracellular Protein Localization Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Epithelial Cell Differentiation Ciliary Basal Body Organization Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Differentiation In Thymus Axoneme Assembly Establishment Of Apical/basal Cell Polarity Metanephric Part Of Ureteric Bud Development Negative Regulation Of T Cell Proliferation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Negative Regulation Of B Cell Activation Leukocyte Migration Cilium Assembly Lung Epithelium Development Epithelium Development Left/right Pattern Formation Glomerular Parietal Epithelial Cell Development Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Lung Ciliated Cell Differentiation
Pathways		Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Cutaneous melanoma or hair colour ( 32341527) Diastolic blood pressure ( 30224653) HOMA-B (corrected for HOMA-IR) ( 30369944) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Insulin resistance/response ( 21901158) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Phenylephrine infusion rate during anesthesia ( 31455332) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: CLK1	8 interacting genes: NMRAL1 OIP5 RFX2 RPUSD1 SLC37A3 THRA TRMT6 TWF2
Entrez ID		57194	2302
HPRD ID		05790	03798
Ensembl ID		ENSG00000206190	ENSG00000129654
Uniprot IDs		O60312	Q92949
PDB IDs
Enriched GO Terms of Interacting Partners?		Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Glomerular Parietal Epithelial Cell Development Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Metanephric Part Of Ureteric Bud Development Ciliary Basal Body Organization Regulation Of Germinal Center Formation Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Tolerance Induction Lung Epithelium Development Left/right Pattern Formation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Tolerance Induction Regulation Of Tolerance Induction Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Regulation Of T Cell Differentiation In Thymus Establishment Or Maintenance Of Monopolar Cell Polarity Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of B Cell Activation Non-membrane Spanning Protein Tyrosine Kinase Activity Motile Cilium Assembly Negative Regulation Of Interleukin-6 Production Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Humoral Immune Response Axoneme Assembly Negative Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Epithelial Cell Differentiation Negative Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Determination Of Bilateral Symmetry Negative Regulation Of Mononuclear Cell Proliferation Microtubule Organizing Center Organization Establishment Of Cell Polarity Determination Of Left/right Symmetry Microtubule Bundle Formation Negative Regulation Of Leukocyte Proliferation Regulation Of Non-canonical NF-kappaB Signal Transduction
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