NIPAL3 and MANBAL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NIPAL3	MANBAL
Description		NIPA like domain containing 3	mannosidase beta like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Membrane
	Molecular Function	Protein Binding Magnesium Ion Transmembrane Transporter Activity	Protein Binding
	Biological Process	Magnesium Ion Transport Magnesium Ion Transmembrane Transport
Pathways		Miscellaneous transport and binding events
Drugs
Diseases
GWAS		Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Male-pattern baldness ( 28196072)	Appendicular lean mass ( 33097823)
Interacting Genes		9 interacting genes: ATP6V0C CD79A GJA5 GPX8 LMNA MANBAL MFF TMEM14B VMA21	21 interacting genes: ATP13A1 CACNA1A CATSPERH CMTM2 GPR151 KLK5 MALL MARCHF5 MPDU1 NIPAL3 OTOP2 PIGF SCRG1 SLC39A9 STX3 TMBIM6 TMEM115 TMEM203 UBQLN1 VKORC1 VTI1B
Entrez ID		57185	63905
HPRD ID		13149	14356
Ensembl ID		ENSG00000001461	ENSG00000101363
Uniprot IDs		A6NN97 Q6P499	A2A2E0 Q9NQG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Lysosomal Lumen Acidification Intracellular PH Reduction Regulation Of Lysosomal Lumen PH Vacuolar Acidification Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Regulation Of Cellular PH Regulation Of Intracellular PH Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Foramen Ovale Closure Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Regulation Of Bundle Of His Cell Action Potential Cell Communication By Chemical Coupling Pulmonary Valve Formation SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Regulation Of PH IgM B Cell Receptor Complex Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Renin Secretion Into Blood Stream Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of AV Node Cell Action Potential Regulation Of Mitochondrion Organization B Cell Receptor Complex Regulation Of Atrial Cardiac Muscle Cell Action Potential Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication Negative Regulation Of Glomerular Filtration AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Gap Junction Hemi-channel Activity Connexin Binding Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Lamin Filament Nuclear Pore Localization Vacuolar Proton-transporting V-type ATPase Complex Assembly SA Node Cell Action Potential Atrioventricular Valve Development	Membrane Endoplasmic Reticulum Membrane Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Monoatomic Ion Transport Metal Ion Transport Endoplasmic Reticulum SNARE Complex Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane SNAP Receptor Activity Intracellular Calcium Ion Homeostasis Endoribonuclease Inhibitor Activity Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Negative Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Autophagosome Maturation Presynaptic Endosome Membrane Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vesicle Docking Monoatomic Ion Homeostasis SNARE Binding Negative Regulation Of Cation Transmembrane Transport Chemical Homeostasis Ethanolaminephosphotransferase Activity Intracellular Chemical Homeostasis Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Toll-like Receptor 3 Signaling Pathway P-type Transmembrane Transporter Activity
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