DUSP22 and PTP4A2

Number of citations: 81 (PubMedID 36300783)
Data Source: BioGRID (pull down)

		DUSP22	PTP4A2
Name		dual specificity phosphatase 22	protein tyrosine phosphatase 4A2
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Filamentous Actin Leading Edge Of Lamellipodium	Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Protein Tyrosine Kinase Inhibitor Activity Protein Tyrosine Kinase Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of JNK Cascade T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Focal Adhesion Assembly Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus	None
Pathways		None	RAB geranylgeranylation
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Albumin-globulin ratio ( 29403010 ) Alopecia areata ( 25608926 ) Asthma (childhood onset) ( 31036433 ) Crohn's disease ( 26192919 ) Eosinophil count ( 32888494 ) Inflammatory bowel disease ( 26192919 ) Male-pattern baldness ( 28196072 ) Non-albumin protein levels ( 29403010 ) Serum total protein levels ( 29403010 ) Systemic lupus erythematosus ( 33536424 ) Takayasu arteritis ( 30498034 )	Appendicular lean mass ( 33097823 ) Body mass index ( 26426971 )
Interacting Genes		6 interacting genes: HOXA1 MAP2K4 MAP2K7 MAPK14 MAPK8 PTP4A2	13 interacting genes: AKAP8L ATF7 CARS1 CNNM1 CNNM3 DHX15 DUSP22 EWSR1 HSP90AA1 HSP90AB1 MPO RABGGTB WIPF2
Entrez ID		56940	8073
HPRD ID		13255	03348
Ensembl ID		ENSG00000112679	ENSG00000184007
Uniprot IDs		A0A384NLC8 Q9NRW4	Q12974
PDB IDs		1WRM 4WOH 6L1S 6LMY 6LOT 6LOU 6LVQ 7C8S	5K22 5K23 5K25 6WUR
GO Terms Enriched among Interactors		Cellular Senescence MAP Kinase Activity MAP Kinase Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Fc-epsilon Receptor Signaling Pathway JUN Kinase Kinase Activity MAPK Cascade Fc Receptor Signaling Pathway JNK Cascade Response To Light Stimulus Protein Serine Kinase Activity Protein Phosphatase Binding Protein Serine/threonine Kinase Activity Response To Radiation Protein Kinase Activity Regulation Of Motor Neuron Apoptotic Process Response To UV Cellular Response To Lipopolysaccharide Positive Regulation Of Cyclase Activity Kinase Activity Cellular Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Canonical Inflammasome Complex Assembly Intracellular Signaling Cassette Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Immune Response Response To Molecule Of Bacterial Origin Enzyme Binding Energy Homeostasis Immune Response-regulating Signaling Pathway Cellular Response To Mechanical Stimulus Semicircular Canal Formation JUN Phosphorylation Cellular Response To Lipid ATP Binding Abducens Nerve Formation Optokinetic Behavior Response To Tumor Necrosis Factor Protein Tyrosine Kinase Activity Cellular Response To Stress Regulation Of Immune System Process Regulation Of Synaptic Membrane Adhesion JUN Kinase Activity Smooth Muscle Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Transferase Activity Nucleotide Binding Intracellular Signal Transduction	Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Magnesium Ion Homeostasis Axonal Growth Cone Chaperone-mediated Protein Complex Assembly RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Telomere Maintenance Via Telomerase Histone Deacetylase Binding Disordered Domain Specific Binding DNA Polymerase Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Protein Tyrosine Kinase Binding Tau Protein Binding CTP Binding DATP Binding Cellular Response To Heat Hypochlorous Acid Biosynthetic Process Protein Folding Chaperone Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation Double-stranded RNA Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex Response To Gold Nanoparticle U2-type Post-mRNA Release Spliceosomal Complex Response To Alkaloid DNA Biosynthetic Process Response To Unfolded Protein Rho GDP-dissociation Inhibitor Binding Chromosome Organization Response To Heat Neuronal Cell Body Response To Transition Metal Nanoparticle Leading Edge Of Lamellipodium ATP Hydrolysis Activity Telomere Maintenance Melanosome Phagocytic Vesicle Lumen Rab-protein Geranylgeranyltransferase Complex