PSMB1 and UBD

Number of citations of the paper that reports this interaction (PubMedID 37012049)
67

Data Source:
BioGRID (pull down)

		PSMB1	UBD
Description		proteasome 20S subunit beta 1	ubiquitin like modifier D
Image
GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome
	Molecular Function	Protein Binding	Protein Binding Proteasome Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Type II Interferon Response To Tumor Necrosis Factor Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Aggresome Assembly Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Neddylation
Drugs		Bortezomib (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Carfilzomib
Diseases
GWAS		Blood protein levels ( 30072576) Type 1 diabetes ( 21980299)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Fish- and plant-related diet ( 32066663) Height ( 25429064) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		105 interacting genes: AGR2 AHSP ARNT2 BEND7 BIRC7 BPIFA1 CAMK2G CCM2L CDC14B CDC42 CDKN1B CEBPA CLPP COG6 CTAG1A CTAG1B CYTH4 DCP2 EXOSC6 FAM136A FAM50B FANCG GADD45GIP1 GEMIN2 GEMIN4 GPBP1 GRIPAP1 GTPBP2 HMG20A HOXA1 IMPACT INSIG2 JAKMIP1 KATNBL1 KHDC4 KIFC3 KRT13 KRT15 KRT31 KRT34 KRT36 KRT40 KRTAP15-1 KRTAP19-1 KRTAP19-7 KRTAP7-1 LCE1C LCE1F LDB2 LENG1 LHX3 LIN7B LMO1 LZTFL1 MAPRE3 MKRN3 MLKL MRNIP MTUS2 NANOS3 NME4 OIP5 OTUD7B PIP4K2B PLEKHG4 PLK1 POMP PSEN1 PSMB3 PSMB5 PSMB7 PSMG3 PYCR3 RIPPLY3 RPRD1B RWDD2A RYBP SCARA5 SERPINB2 SH3GL1 SMAD3 SMARCB1 SNCA STMN2 TFPT THAP6 TLE5 TOLLIP TRAF1 TRAF2 TRIM23 TRIM27 TRIM39 TTC33 UBASH3B UBD VAX1 WEE2-AS1 XPA ZBTB32 ZNF177 ZNF438 ZNF559-ZNF177 ZNF688 ZNF774	29 interacting genes: MAD2L1 NUB1 OTUB1 PDE9A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMD2 PSMD4 SAE1 SRPK1 SRPK2 TGFBR1 UBA2 UBA6 UBE2D2 UBE2Z USP16
Entrez ID		5689	10537
HPRD ID		03603	09354
Ensembl ID		ENSG00000008018	ENSG00000213886
Uniprot IDs		A0A140VK45 P20618	A0A1U9X8S6 O15205
PDB IDs		4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5L5B 5L5D 5L5E 5L5F 5L5H 5L5I 5L5J 5L5O 5L5P 5L5Q 5L5R 5L5S 5L5T 5L5U 5L5V 5L5W 5L5X 5L5Y 5L5Z 5L60 5L61 5L62 5L63 5L64 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M2B 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8QYN 8QYO 8QYS 8QZ9 8TM6 8UD9 8YIX 8YIY 8YIZ 9E8G 9E8O 9E8Q 9HMN	2MBE 6GF1 6GF2 7PYV 9E8O
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Intermediate Filament Epithelial Cell Differentiation Structural Constituent Of Skin Epidermis Intermediate Filament Organization Negative Regulation Of Transcription By RNA Polymerase II Thioesterase Binding Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Proteasome Core Complex, Beta-subunit Complex Mitotic G2 DNA Damage Checkpoint Signaling Proteasome Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Supramolecular Fiber Organization Proteasome Core Complex Nucleus Mitotic G2/M Transition Checkpoint Regulation Of Protein Localization To Cell Periphery Inner Ear Development	Proteasome Core Complex Proteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Proteasome Core Complex, Alpha-subunit Complex Protein Catabolic Process Protein Metabolic Process Proteasome Core Complex, Beta-subunit Complex Nucleoplasm Catabolic Process Macromolecule Metabolic Process Nucleus Cytosol Extracellular Exosome Threonine-type Endopeptidase Activity Ubiquitin-like Modifier Activating Enzyme Activity Secretory Granule Lumen Ficolin-1-rich Granule Lumen SUMO Activating Enzyme Activity SUMO Activating Enzyme Complex Cytoplasm Ubiquitin Activating Enzyme Activity Endopeptidase Activity Small Protein Activating Enzyme Binding Protein Modification Process Post-translational Protein Modification Proteasome Regulatory Particle, Base Subcomplex Positive Regulation Of Protein Sumoylation Proteasome Accessory Complex P-body Regulation Of Protein Sumoylation Regulation Of Post-translational Protein Modification Peptidase Activity Protein Modification By Small Protein Conjugation Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ubiquitin Conjugating Enzyme Activity Lipopolysaccharide Binding Purine Ribonucleoside Triphosphate Binding Positive Regulation Of Ribosome Biogenesis FAT10 Activating Enzyme Activity Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication
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