PSMA2 and PSMB10

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical)

		PSMA2	PSMB10
Description		proteasome 20S subunit alpha 2	proteasome 20S subunit beta 10
Image
GO Annotations	Cellular Component	Proteasome Complex P-body Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Spermatoproteasome Complex
	Molecular Function	Protein Binding	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Response To Virus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Cell Morphogenesis Proteolysis Humoral Immune Response T Cell Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs		(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE	Carfilzomib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Crohn's disease ( 22412388) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: CCNA1 CEBPA HOMER3 NFKBIA PSMA1 PSMA3 PSMA4 PSMA6 PSMA7 PSMB10 PSMB5 UBD	11 interacting genes: ANXA7 CCNDBP1 CRX MEOX2 POMP PSMA1 PSMA2 PSMA3 PSMB8 PSMB9 PTN
Entrez ID		5683	5699
HPRD ID		08907	01465
Ensembl ID		ENSG00000106588	ENSG00000205220
Uniprot IDs		A0A024RA52 P25787	P40306
PDB IDs		4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8JRI 8JRT 8JTI 8K0G 8QYJ 8QYL 8QYM 8QYN 8QYO 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8UD9 8USB 8USC 8YIX 8YIY 8YIZ 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q 9HMN	6AVO 6E5B 6HV3 6HV4 6HV5 6HV7 6HVA 6HVR 6HVS 6HVT 6HVU 6HVV 6HVW 7AWE 7B12 9FSV
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Complex Proteasome Core Complex, Alpha-subunit Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Catabolic Process Nucleoplasm Threonine-type Endopeptidase Activity Cytosol Proteasome Core Complex, Beta-subunit Complex Endopeptidase Activity Response To Tumor Necrosis Factor Nucleus Regulation Of Inflammatory Response Protein Metabolic Process NF-kappaB Binding Cytoplasm RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Purine Ribonucleoside Triphosphate Binding Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Response To Vitamin B2 C/EBP Complex Regulation Of Canonical NF-kappaB Signal Transduction Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Extracellular Exosome Regulation Of DNA-templated Transcription Initiation Regulation Of Defense Response CHOP-C/EBP Complex Cellular Response To Tumor Necrosis Factor I-kappaB/NF-kappaB Complex P-body Cyclin A2-CDK2 Complex G Protein-coupled Glutamate Receptor Binding Notch Signaling Pathway White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Spermatoproteasome Complex Nuclear Matrix Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Aggresome Assembly Myeloid Leukocyte Differentiation	Proteasome Core Complex Proteasome Complex Proteasome Core Complex, Alpha-subunit Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spermatoproteasome Complex Proteasomal Protein Catabolic Process Threonine-type Endopeptidase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome Core Complex, Beta-subunit Complex Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nucleus Macromolecule Catabolic Process Proteolysis Catabolic Process Extracellular Exosome Dendrite Regeneration Endopeptidase Activity Ossification Involved In Bone Remodeling Nuclear Speck
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