TMPRSS4 and NLRX1

		TMPRSS4	NLRX1
Description		transmembrane serine protease 4	NLR family member X1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Secretory Granule	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Proteolysis Response To Wounding Regulation Of Gene Expression Protein Processing Negative Regulation Of Growth Rate Positive Regulation Of Viral Entry Into Host Cell	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS			Mean reticulocyte volume ( 32888494)
Interacting Genes		14 interacting genes: BNIP3L CLEC7A CLRN1 ERVFRD-1 FAM209A FNDC9 GPX8 KASH5 LMNA RASGRP4 SIGLEC12 SUSD3 SYNE4 TMEM79	1 interacting genes: SARM1
Entrez ID		56649	79671
HPRD ID		05952	17640
Ensembl ID		ENSG00000137648	ENSG00000160703
Uniprot IDs		A0AAQ5BHV4 B7Z458 B7Z8X1 B7Z900 E7ESG9 Q9NRS4	A0A9L9PX86 Q86UT6
PDB IDs			3UN9
Enriched GO Terms of Interacting Partners?		Nuclear Envelope Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity
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