INPP5E and KTN1

		INPP5E	KTN1
Description		inositol polyphosphate-5-phosphatase E	kinectin 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Ruffle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Golgi Cisterna Membrane Cell Projection Plasma Membrane Bounded Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-4,5-bisphosphate Phosphatase Activity	RNA Binding Protein Binding Kinesin Binding Cadherin Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Negative Regulation Of Translation Organophosphate Metabolic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cilium Assembly Response To Inositol Negative Regulation Of Protein Localization To Cilium	Microtubule-based Movement Protein Transport
Pathways		Synthesis of PIPs at the Golgi membrane ARL13B-mediated ciliary trafficking of INPP5E	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases		Joubert syndrome
GWAS		Crohn's disease ( 28067908) Granulocyte count ( 27863252) Hemoglobin A1c levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Red cell distribution width ( 32888494) Serum total protein levels ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908 21297633) White blood cell count ( 27863252 32888494)	Brain morphology (MOSTest) ( 32665545) Early spontaneous preterm birth ( 31194736) Lean body mass ( 28552196) Neurofibrillary tangles ( 31497858) Plasma anti-thyroglobulin levels ( 29678681) Subcortical brain region volumes ( 25607358)
Interacting Genes		1 interacting genes: YWHAG	31 interacting genes: ABI1 BNIP3 CD3G CD68 CDC42 CLEC4C CLEC7A EEF1D FFAR2 FILNC1 IKBKE KIF5B KIR2DL3 LHFPL5 M6PR MEOX2 PDCD1LG2 PLEKHA5 RAC1 RHOA RHOG RNF10 SGTA SIRPA SLC71A2 STOM SUSD3 SYNE4 SYNPR TMEM179B UBE2I
Entrez ID		56623	3895
HPRD ID		17151	02661
Ensembl ID		ENSG00000148384	ENSG00000126777
Uniprot IDs		Q9NRR6	Q86UP2
PDB IDs		2XSW
Enriched GO Terms of Interacting Partners?			Ficolin-1-rich Granule Membrane Establishment Or Maintenance Of Cell Polarity Secretory Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Membrane Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Glutamatergic Synapse G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Immune System Process Membrane Invagination Actin Filament Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway Azurophil Granule Membrane Thioesterase Binding Regulation Of Interleukin-23 Production Regulation Of Synapse Organization Positive Regulation Of Actin Filament Bundle Assembly Immune Response Tertiary Granule Membrane Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Antifungal Innate Immune Response G Protein Activity Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Cellular Response To Type II Interferon Positive Regulation Of Immune System Process Regulation Of Immune System Process Response To External Biotic Stimulus Positive Regulation Of Protein Localization To Membrane Regulation Of Respiratory Burst Regulation Of Modification Of Synaptic Structure Establishment Of Cell Polarity GTP-dependent Protein Binding Regulation Of Stress Fiber Assembly Regulation Of Cell Maturation Postsynapse Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Type II Interferon Regulation Of Chemokine Production Rac Protein Signal Transduction
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