INPP5E

Gene Name		inositol polyphosphate-5-phosphatase, 72 kDa
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Gene Ontology Annotations	Cellular Component	Ruffle Cytosol Cytoskeleton Plasma Membrane Axoneme Golgi Cisterna Membrane Primary Cilium
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Organelle Organization Biological_process Small Molecule Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Synthesis of PIPs at the Golgi membrane ARL13B-mediated ciliary trafficking of INPP5E Metabolism of lipids and lipoproteins Assembly of the primary cilium Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-protein Interactions		1 interactors: YWHAG
Entrez ID		56623
HPRD ID		17151
Ensembl ID		ENSG00000148384
Uniprot IDs		Q9NRR6
PDB IDs		2XSW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization
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