CYP26B1 and CEBPG

		CYP26B1	CEBPG
Description		cytochrome P450 family 26 subfamily B member 1	CCAAT enhancer binding protein gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Retinoic Acid Binding Monooxygenase Activity Iron Ion Binding Protein Binding Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding All-trans Retinoic Acid 18-hydroxylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Fate Determination Establishment Of T Cell Polarity Kidney Development Lipid Metabolic Process Vitamin Metabolic Process Xenobiotic Metabolic Process Inflammatory Response Male Meiotic Nuclear Division Spermatogenesis Central Nervous System Development Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Embryonic Limb Morphogenesis Response To Retinoic Acid Response To Vitamin A Retinoic Acid Catabolic Process Retinoic Acid Metabolic Process Tongue Morphogenesis Regulation Of T Cell Differentiation Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Bone Morphogenesis Establishment Of Skin Barrier Cornification Cellular Response To Retinoic Acid Positive Regulation Of Tongue Muscle Cell Differentiation	Liver Development DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response MRNA Metabolic Process B Cell Differentiation Positive Regulation Of Type II Interferon Production Natural Killer Cell Mediated Cytotoxicity Enucleate Erythrocyte Differentiation Positive Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Integrated Stress Response Signaling
Pathways		Vitamins RA biosynthesis pathway Defective CYP26B1 causes RHFCA	ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Tretinoin
Diseases
GWAS		Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Heel bone mineral density ( 30598549) Height ( 31562340) IgA levels ( 28628107) Malaria ( 31844061) Mitochondrial heteroplasmy measurement ( 33731350) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Schizophrenia ( 25056061) Serum metabolite levels ( 33031748)	Inflammatory bowel disease ( 23128233) Pancreas fat ( 34128465) Schizophrenia ( 26198764) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		1 interacting genes: NEDD4L	24 interacting genes: ATF2 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CEBPA CEBPB CEBPD CEBPE CREB3 CREB3L3 DBP DDIT3 FOS FOSL1 GTF2F2 JUN MLLT6 NFE2L2 PFDN6 PLAU POLR2M
Entrez ID		56603	1054
HPRD ID		05550	00738
Ensembl ID		ENSG00000003137	ENSG00000153879
Uniprot IDs		E7ER08 Q9NR63	P53567
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Internalization Prenylcysteine Oxidase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Oxygen As Acceptor Prenylcysteine Catabolic Process Farnesylcysteine Lyase Activity Prenylated Protein Catabolic Process Receptor-mediated Endocytosis Core TFIIH Complex Portion Of Holo TFIIH Complex Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Enucleate Erythrocyte Differentiation Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity	RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Intracellular Signaling Cassette Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Stress CAMP Response Element Binding Protein Binding Response To Endoplasmic Reticulum Stress RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Myeloid Leukocyte Differentiation CHOP-C/EBP Complex DNA-templated Transcription Mononuclear Cell Differentiation Macromolecule Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Leukocyte Differentiation Myeloid Cell Differentiation Nucleobase-containing Compound Biosynthetic Process Sequence-specific DNA Binding Nucleus Response To Nutrient Levels Liver Development
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