PROX1 and NEK2

		PROX1	NEK2
Description		prospero homeobox 1	NIMA related kinase 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Midbody Nuclear Lumen Protein-containing Complex Ciliary Basal Body Intercellular Bridge
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Nuclear Receptor Binding Sequence-specific DNA Binding DNA Binding Domain Binding LBD Domain Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Lymphangiogenesis Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Hepatocyte Cell Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Central Nervous System Development Brain Development Circadian Rhythm Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Epithelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Tube Development Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of Viral Genome Replication Cell Fate Commitment Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lens Placode Formation Involved In Camera-type Eye Formation Rhythmic Process Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Determination Inner Ear Development Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Blood Vessel Endothelial Cell Differentiation Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Population Maintenance Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion
Pathways			APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs			5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Blood glucose levels ( 31928498) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Hematocrit ( 29403010 32888494 27863252) Hemoglobin ( 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) HIV-1 progression ( 20064070) Homeostasis model assessment of beta-cell function ( 20081858) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monoclonal gammopathy of undetermined significance ( 30737484) Obesity ( 23818313) Pancreas volume ( 34128465) Red blood cell count ( 29403010 32888494 27863252) Refractive error ( 32231278) Rheumatic heart disease ( 34106200) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 25961943) Type 2 diabetes ( 30297969 32499647 29358691 28566273 24509480 22885922) Type 2 diabetes (age of onset) ( 28060188)	Red cell distribution width ( 27863252 28957414 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		17 interacting genes: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3	29 interacting genes: CDC20 CEP250 CHGA CIP2A CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PIN1 PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3
Entrez ID		5629	4751
HPRD ID		03330	04953
Ensembl ID		ENSG00000117707	ENSG00000117650
Uniprot IDs		Q92786	F6U4U2 P51955
PDB IDs		2LMD	2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Sequence-specific DNA Binding Chromatin Transcription Coregulator Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription Coactivator Binding Sequence-specific Double-stranded DNA Binding Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Estrogen Response Element Binding Rhythmic Process Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Signal Transduction Chromatin Binding Metal Ion Binding Nucleus Histone H3K27 Acetyltransferase Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity	Centrosome Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Ciliary Basal Body Positive Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Ubiquitin Ligase Activator Activity Positive Regulation Of Organelle Organization Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Checkpoint Regulation Of Microtubule Nucleation Neuron Cellular Homeostasis Regulation Of Centriole-centriole Cohesion Neuronal Cell Body Axon Initial Segment Regulation Of Nuclear Division Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Cell Cycle Phase Transition Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Spindle Pole Regulation Of Cell Cycle Acinar Cell Differentiation Synapse Organization Chromosome, Centromeric Region Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Microtubule Polymerization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Hematopoietic Or Lymphoid Organ Development Cell Division Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Trachea Formation PTW/PP1 Phosphatase Complex Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Cytoskeleton Cytosol Regulation Of Circadian Rhythm
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