CFC1 and NDUFS1

		CFC1	NDUFS1
Description		cryptic, EGF-CFC family member 1	NADH:ubiquinone oxidoreductase core subunit S1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Side Of Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Respiratory Chain Complex I
	Molecular Function	Nodal Binding Activin Receptor Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Blood Vessel Development Signal Transduction Determination Of Left/right Symmetry Gastrulation Heart Development Anterior/posterior Pattern Specification Nodal Signaling Pathway	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Cellular Respiration Proton Transmembrane Transport
Pathways		Signaling by NODAL Regulation of signaling by NODAL	Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs			NADH
Diseases		Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Heterotaxy; Situs ambiguus	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Body mass index ( 26426971) Chronotype ( 30696823) Daytime nap ( 33568662) Frontotemporal dementia with GRN mutation ( 29724592) Morning person ( 30696823)
Interacting Genes			5 interacting genes: C1QTNF9 CASP3 KDM1A MDH2 MDM2
Entrez ID		55997	4719
HPRD ID		05548	01145
Ensembl ID		ENSG00000136698	ENSG00000023228
Uniprot IDs		A0A087WWV2 A0A087WX98 P0CG37	E5KRK5 P28331
PDB IDs			5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?			Death-inducing Signaling Complex Death Receptor Binding Response To Ionizing Radiation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To UV Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Gamma Radiation Cellular Response To Alkaloid Response To Steroid Hormone Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Apoptotic Signaling Pathway Response To Antibiotic Heart Development Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Hypoxia Response To Decreased Oxygen Levels Response To Light Stimulus Response To Gamma Radiation Response To Oxygen Levels Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process L-malate Dehydrogenase (NADP+) Activity P53 Binding Cellular Response To Ionizing Radiation Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Apoptotic Signaling Pathway Enzyme Activator Activity Response To Alkaloid Response To Radiation Cellular Response To UV Regulation Of Neuron Projection Development Protease Binding Response To Hydrogen Peroxide Phospholipase A2 Activator Activity Cellular Response To Light Stimulus Response To Toxic Substance Skeletal Myofibril Assembly Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Response To Estradiol Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cysteine-type Peptidase Activity Response To Glucocorticoid L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Response To Vitamin B1 Response To Water-immersion Restraint Stress
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