CMAS and SIGLEC12

Number of citations of the paper that reports this interaction (PubMedID 11546777)
0

Data Source:
HPRD (in vitro)

		CMAS	SIGLEC12
Description		cytidine monophosphate N-acetylneuraminic acid synthetase	sialic acid binding Ig like lectin 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Plasma Membrane Membrane
	Molecular Function	N-acylneuraminate Cytidylyltransferase Activity Transferase Activity Nucleotidyltransferase Activity	Protein Binding Carbohydrate Binding Sialic Acid Binding
	Biological Process	N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Glycosylation	Cell Adhesion
Pathways		Sialic acid metabolism	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Cytidine-5'-Monophosphate-5-N-Acetylneuraminic Acid
Diseases
GWAS		Entorhinal cortical thickness ( 21116278)
Interacting Genes		5 interacting genes: APP KCNJ6 PTEN RSPH1 SIGLEC12	17 interacting genes: ACSF2 ADIPOQ ATP5PF CDIPT CLEC4G CMAS CTSA DNAJC30 IL1RL1 MGST1 PLPP6 PLPPR2 PTCH1 PTPN11 PTPN6 TMPRSS4 YIPF1
Entrez ID		55907	89858
HPRD ID		04501	16195
Ensembl ID		ENSG00000111726	ENSG00000254521
Uniprot IDs		Q8NFW8	Q96PQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Radial Spoke Head 1 Radial Spoke Head 3 Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Developmental Maturation Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Microtubule-based Process Main Axon Locomotory Behavior Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling G-protein Activated Inward Rectifier Potassium Channel Activity	Regulation Of Neutrophil Activation Phosphate-containing Compound Metabolic Process Dephosphorylation Organophosphate Metabolic Process Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Adaptive Immune Response Negative Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Proliferation Neutrophil Activation Involved In Immune Response Brain Development Phosphatidate Phosphatase Activity Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Immune System Process Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Adhesion Platelet Formation Megakaryocyte Development Positive Regulation Of Viral Life Cycle Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Transport Negative Regulation Of T Cell Activation Negative Regulation Of Cytokine Production Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Cell Activation Lipid Modification Cellular Response To Lipid Hydroperoxide Negative Regulation Of Cell Population Proliferation Neural Plate Axis Specification Regulation Of Cholesterol Efflux Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cholesterol Transport Reproductive Structure Development Cytokine-mediated Signaling Pathway Regulation Of T Cell Proliferation Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Regulation Of Tumor Necrosis Factor Production T Cell Costimulation Regulation Of Cytokine-mediated Signaling Pathway Epididymis Development Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport
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