CMAS and SIGLEC12

Number of citations of the paper that reports this interaction (PMID 11546777)
9

Data Source:
HPRD (in vitro)

		CMAS	SIGLEC12
Gene Name		cytidine monophosphate N-acetylneuraminic acid synthetase	sialic acid binding Ig-like lectin 12 (gene/pseudogene)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Integral Component Of Membrane
	Molecular Function	N-acylneuraminate Cytidylyltransferase Activity	Carbohydrate Binding
	Biological Process	N-acetylneuraminate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process	Cell Adhesion
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Entorhinal cortical thickness ( 21116278)
Protein-Protein Interactions		2 interactors: APP SIGLEC12	3 interactors: CMAS PTPN11 PTPN6
Entrez ID		55907	89858
HPRD ID		04501	16195
Ensembl ID		ENSG00000111726	ENSG00000254521
Uniprot IDs		Q8NFW8	Q96PQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Adhesion Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing Cholesterol Metabolic Process Adult Locomotory Behavior Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity	Abortive Mitotic Cell Cycle Megakaryocyte Development Platelet Formation Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Megakaryocyte Differentiation Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway T Cell Costimulation Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Response To Interferon-gamma Peptidyl-tyrosine Dephosphorylation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Bone Development Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Myeloid Cell Differentiation Protein Dephosphorylation Negative Regulation Of Glucocorticoid Secretion Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Lymphocyte Activation Regulation Of Mitotic Cell Cycle Blood Coagulation Hemostasis Regulation Of Intracellular Transport N-acetylneuraminate Metabolic Process Cytokine-mediated Signaling Pathway
Tagcloud ?		become biomarkers cadherin catalogs cd44 concept concordance constructed correlates creating easy epcam immortalized immunocytochemical invaluable labeling laboratories microarrays phosphoproteins proof publicly screen subcellular throughput tmas tool utility validate
Tagcloud (Difference) ?		become biomarkers cadherin catalogs cd44 concept concordance constructed correlates creating easy epcam immortalized immunocytochemical invaluable labeling laboratories microarrays phosphoproteins proof publicly screen subcellular throughput tmas tool utility validate
Tagcloud (Intersection) ?