USE1 and CALN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		USE1	CALN1
Description		unconventional SNARE in the ER 1	calneuron 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane COPI-coated Vesicle SNARE Complex	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	SNAP Receptor Activity Protein Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endoplasmic Reticulum Organization Lysosomal Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Secretion By Cell Regulation Of ER To Golgi Vesicle-mediated Transport Membrane Fusion Endoplasmic Reticulum Tubular Network Organization
Pathways		COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Night sleep phenotypes ( 27126917)	Age at first birth ( 34211149) Airflow obstruction ( 22837378) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 29422769) Emotional recognition ( 32366958) Femur bone mineral density x serum urate levels interaction ( 34046847) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Logical memory (delayed recall) in normal cognition ( 29274321) Refractive error ( 32231278) Schizophrenia ( 30285260 28991256) Sedentary behaviour duration ( 30531941) Triglyceride levels ( 32154731 32203549)
Interacting Genes		18 interacting genes: APOL2 APP AQP6 BSCL2 CALN1 CCDC70 CCM2L CREB3 EBP JAGN1 LMNA MEOX2 SCN3B SLC71A2 STX1A STX4 TMEM86B TRIM27	9 interacting genes: DNAJC30 FATE1 LIME1 MAL PLP1 SEC22A SLPI SYCE1L USE1
Entrez ID		55850	83698
HPRD ID		11299	06209
Ensembl ID		ENSG00000053501	ENSG00000183166
Uniprot IDs		Q9NZ43	A4D1Z1 Q9BXU9
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Lipoprotein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Fungus Positive Regulation Of Synaptic Transmission Response To Fungus Regulation Of Protein Localization Lipoprotein Particle Regulation Of Protein Transport Positive Regulation Of Monocyte Chemotaxis Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Protein Import Modulation Of Excitatory Postsynaptic Potential Regulation Of Monocyte Chemotaxis Identical Protein Binding PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Membrane Structural Constituent Of Nuclear Lamina Protein Sumoylation SNARE Complex Regulation Of Insulin Secretion Insulin Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Peptide Hormone Secretion SNARE Complex Assembly SNAP Receptor Activity Myosin Head/neck Binding SNARE Binding Vesicle Docking Exocytosis Positive Regulation Of Eosinophil Degranulation Sphingomyelin Phosphodiesterase Activator Activity Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Storage Vacuole Endoplasmic Reticulum Membrane Positive Regulation Of Deacetylase Activity	Structural Constituent Of Myelin Sheath Central Nervous System Myelination SNAP Receptor Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Myelination Axon Ensheathment Protein Localization To Paranode Region Of Axon Membrane Raft Polarization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport B Cell Receptor Complex Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport Negative Regulation Of Mitochondrial Calcium Ion Concentration
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