IARS2 and MTARC1

		IARS2	MTARC1
Description		isoleucyl-tRNA synthetase 2, mitochondrial	mitochondrial amidoxime reducing component 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Outer Membrane Membrane Nitric-oxide Synthase Complex
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Isoleucine-tRNA Ligase Activity ATP Binding Ligase Activity	Catalytic Activity Protein Binding Nitrate Reductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Molybdenum Ion Binding Pyridoxal Phosphate Binding Molybdopterin Cofactor Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity Nitrite Reductase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Mitochondrial Translation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	Nitric Oxide Biosynthetic Process Nitrate Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound
Pathways		Mitochondrial tRNA aminoacylation Mitochondrial protein degradation	Phase I - Functionalization of compounds
Drugs		Isoleucine
Diseases
GWAS		Iron status biomarkers (ferritin levels) ( 33536631)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874)
Interacting Genes		4 interacting genes: APP ERCC6 HSPB1 YWHAQ	2 interacting genes: EPHB6 NAA11
Entrez ID		55699	64757
HPRD ID		13334	08653
Ensembl ID		ENSG00000067704	ENSG00000186205
Uniprot IDs		Q9NSE4	Q5VT66
PDB IDs			6FW2
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Positive Regulation Of Interleukin-1 Production Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Axo-dendritic Transport Regulation Of Response To Calcium Ion Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemotaxis Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Interleukin-1 Beta Production Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Interleukin-1 Beta Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Inhibitor Activity Nitric-oxide Synthase Complex Nitrate Reductase Activity Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Nitrate Metabolic Process Molybdenum Ion Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Cytoskeleton-dependent Intracellular Transport Regulation Of Chemotaxis Axon Midline Choice Point Recognition Intracellular Signaling Cassette Regulation Of Tumor Necrosis Factor Production Transport Along Microtubule Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response	Detoxification Of Zinc Ion Manganese Ion Export Across Plasma Membrane Calcium:manganese Antiporter Activity Isoleucine-tRNA Ligase Activity Isoleucyl-tRNA Aminoacylation Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Patched Ligand Maturation Protein N-terminal-serine Acetyltransferase Activity Manganese Ion Transmembrane Transporter Activity Intracellular Manganese Ion Homeostasis Manganese Ion Homeostasis Protein-N-terminal Amino-acid Acetyltransferase Activity NatA Complex Zinc Ion Import Into Organelle Manganese Ion Transmembrane Transport Manganese Ion Transport Aminoacyl-tRNA Metabolism Involved In Translational Fidelity Aminoacyl-tRNA Deacylase Activity 9+0 Non-motile Cilium Regulation Of Response To Drug N-terminal Protein Amino Acid Acetylation Diaphragm Development Molecular Carrier Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Cellular Response To Angiotensin Intracellular Copper Ion Homeostasis Monoatomic Cation Transmembrane Transporter Activity Regulation Of Translational Fidelity Protein Maturation Copper Ion Homeostasis Skeletal Muscle Organ Development
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