IARS2

Description		isoleucyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Isoleucine-tRNA Ligase Activity ATP Binding Ligase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Mitochondrial Translation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways		Mitochondrial tRNA aminoacylation Mitochondrial protein degradation
Drugs		Isoleucine
Diseases
GWAS		Iron status biomarkers (ferritin levels) ( 33536631)
Novel Interacting Genes		1 novel interacting genes: MTARC1
Interacting Genes		4 interacting genes: APP ERCC6 HSPB1 YWHAQ
Entrez ID		55699
HPRD ID		13334
Ensembl ID		ENSG00000067704
Uniprot IDs		Q9NSE4
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Positive Regulation Of Interleukin-1 Production Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Axo-dendritic Transport Regulation Of Response To Calcium Ion Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemotaxis Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Interleukin-1 Beta Production Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Interleukin-1 Beta Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Inhibitor Activity Nitric-oxide Synthase Complex Nitrate Reductase Activity Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Nitrate Metabolic Process Molybdenum Ion Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Cytoskeleton-dependent Intracellular Transport Regulation Of Chemotaxis Axon Midline Choice Point Recognition Intracellular Signaling Cassette Regulation Of Tumor Necrosis Factor Production Transport Along Microtubule Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response
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