PIGV and MADCAM1

		PIGV	MADCAM1
Description		phosphatidylinositol glycan anchor biosynthesis class V	mucosal vascular addressin cell adhesion molecule 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mannosyltransferase Complex	Plasma Membrane Membrane
	Molecular Function	Alpha-1,6-mannosyltransferase Activity Mannosyltransferase Activity GPI Mannosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity	Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process	GPI Anchor Biosynthetic Process	Positive Regulation Of Leukocyte Migration Immune Response Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Heterotypic Cell-cell Adhesion Receptor Clustering Leukocyte Tethering Or Rolling Positive Regulation Of Lymphocyte Migration
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Blond vs. brown/black hair color ( 30531825) Blood protein levels in cardiovascular risk ( 28369058) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 27863252) Sum basophil neutrophil counts ( 27863252) Triglyceride levels ( 28334899 32154731) Triglycerides ( 24097068)
Interacting Genes			3 interacting genes: CD44 ITGA4 ITGB7
Entrez ID		55650	8174
HPRD ID		07912	00035
Ensembl ID		ENSG00000060642	ENSG00000099866
Uniprot IDs		A0A6I8PU65 A0A8I5KQ29 A0A8I5KRV8 Q9NUD9	Q13477
PDB IDs			1BQS 1GSM 4HBQ 4HC1 4HCR 4HD9
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Penetration Of Cumulus Oophorus	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Leukocyte Cell-cell Adhesion Immune Response In Gut-associated Lymphoid Tissue Cell-matrix Adhesion Cell-substrate Adhesion Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Integrin Complex Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Focal Adhesion Cell-cell Adhesion Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Negative Regulation Of Protein Homodimerization Activity Cell Adhesion Molecule Binding Mannosyltransferase Complex Integrin-mediated Signaling Pathway Positive Regulation Of Monocyte Aggregation Cell Surface Regulation Of Signal Transduction By P53 Class Mediator Macrophage Migration Inhibitory Factor Receptor Complex Developmental Cell Growth Alpha-1,6-mannosyltransferase Activity Immune System Process Developmental Growth Involved In Morphogenesis Integrin Binding Cell Surface Receptor Signaling Pathway Monocyte Aggregation Integrin Alpha4-beta1 Complex Axonogenesis Intracellular Protein-containing Complex GPI Mannosyltransferase Activity Extracellular Exosome Cell Adhesion Positive Regulation Of Vesicle Transport Along Microtubule Cell Migration C-X3-C Chemokine Binding Leukocyte Migration LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Diapedesis Cell-cell Adhesion Mediated By Integrin Cell Motility Neuron Projection Morphogenesis Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Projection Morphogenesis
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