HES6 and C14orf119

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HES6	C14orf119
Description		hes family bHLH transcription factor 6	chromosome 14 open reading frame 119
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Anterior/posterior Pattern Specification Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis
Pathways
Drugs
Diseases
GWAS		Chronotype ( 30696823) Irritable bowel syndrome ( 25248455)
Interacting Genes		8 interacting genes: C14orf119 CSNK2A1 HES1 KRTAP10-9 MAPK3 RAB2A SMARCD1 TLE1	56 interacting genes: ACTN4 ARID3C ARID5A AUNIP BEND7 BIN3 C1QTNF1 CCND3 CDC14A CHMP1A CLPP CTAG1A CTAG1B DDIT4L DECR2 DYNLL1 DYNLL2 HES6 HLX HMG20B ITGB3BP KHDC4 KRT4 KRT78 KRTAP13-3 LASP1 LDB2 LENG1 LRRCC1 MEOX1 MORN3 MYF5 NIF3L1 NME4 NRIP3 NUP54 NUP62 PBX4 PHACTR1 PINX1 RAB3IL1 REL RHOU RND3 RNF4 RPIA SMCP SNX8 SSX4 SSX4B STN1 SYCP3 TEX35 TLE5 UBXN11 WASHC1
Entrez ID		55502	55017
HPRD ID		11021	16595
Ensembl ID		ENSG00000144485	ENSG00000179933
Uniprot IDs		Q96HZ4	Q9NWQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cardiac Neural Crest Cell Development Involved In Heart Development Macroautophagy Neural Crest Cell Development Positive Regulation Of Cell Population Proliferation Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Stem Cell Development Thymus Development Negative Regulation Of Pancreatic A Cell Differentiation N-box Binding Negative Regulation Of Cell Fate Determination Positive Regulation Of Mitotic Cell Cycle, Embryonic Trochlear Nerve Development Response To Fatty Acid Cellular Response To Fatty Acid Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Positive Regulation Of Macroautophagy Negative Regulation Of Proteolysis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Ureteric Bud Morphogenesis Regulation Of T Cell Activation Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Nuclear Matrix Negative Regulation Of Amacrine Cell Differentiation Oculomotor Nerve Development Regulation Of Lymphocyte Activation Negative Regulation Of Pro-B Cell Differentiation Regulation Of Mitotic Cell Cycle, Embryonic Cajal-Retzius Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Response To Tumor Necrosis Factor Hindbrain Morphogenesis HLH Domain Binding Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis BMP Signaling Pathway	Protein Binding
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