DNAJA4 and SKIC8

		DNAJA4	SKIC8
Description		DnaJ heat shock protein family (Hsp40) member A4	SKI8 subunit of superkiller complex
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Euchromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Ski Complex
	Molecular Function	Protein Binding ATP Binding Zinc Ion Binding Hsp70 Protein Binding Heat Shock Protein Binding Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding	Protein Binding
	Biological Process	Protein Folding Response To Heat Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Protein Refolding Negative Regulation Of Inclusion Body Assembly	Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 27863252 32888494 28957414) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum metabolite levels ( 33031748)
Interacting Genes		3 interacting genes: BANP ERG SH3BP4	11 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 MSRB3 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ
Entrez ID		55466	80349
HPRD ID		09920	15236
Ensembl ID		ENSG00000140403	ENSG00000140395
Uniprot IDs		Q8WW22	H0YL19 Q9GZS3
PDB IDs			3OW8 6GMH 6TED 7OOP 7OPC 7OPD 7QDR 7QDS 7QDY 7QDZ 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9G8O 9G8Q 9G8R
Enriched GO Terms of Interacting Partners?		Amino Acid Kinase Activity Hydroxylysine Kinase Activity Amino Acid Import Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Cdc73/Paf1 Complex Lysine Catabolic Process	Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Activin Receptor Signaling Pathway I-SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Pharyngeal System Development Regulation Of Metabolic Process Regulation Of Gene Expression Transforming Growth Factor Beta Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Mitotic Cell Cycle Phase Transition Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA-templated Transcription Response To Stress Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Keratinocyte Differentiation Ventricular Septum Morphogenesis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding Negative Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Endocardial Cushion Cell Fate Commitment Negative Regulation Of MRNA 3'-end Processing Hepatocyte Homeostasis Type 8 Metabotropic Glutamate Receptor Binding Engulfment Of Target By Autophagosome Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Cycle Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Epidermal Cell Differentiation Gland Development Cellular Response To Growth Factor Stimulus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
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