CCDC198 and IQGAP3

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		CCDC198	IQGAP3
Description		coiled-coil domain containing 198	IQ motif containing GTPase activating protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle	Cytoplasm Cytosol Cell-cell Junction Cell Cortex Lateral Plasma Membrane
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Calmodulin Binding Small GTPase Binding Actin Filament Binding Myosin VI Light Chain Binding
	Biological Process	Energy Homeostasis	G1/S Transition Of Mitotic Cell Cycle Ras Protein Signal Transduction Regulation Of Cell Size Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of MAPK Cascade ERK1 And ERK2 Cascade Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization
Pathways			RHO GTPases activate IQGAPs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs
Diseases
GWAS			Adult body size ( 32376654) Creatine kinase levels ( 29403010)
Interacting Genes		27 interacting genes: CBY2 FAM9B FHL2 FHL3 FKBP6 GOLGA2 GOPC HOOK2 HSF2BP IQGAP3 KIFC3 KRT31 KRT34 KRT40 LZTS2 MDFI MTUS2 PDE4DIP PFDN5 PNMA1 SIAH1 SMAD3 SSX2IP TEX11 TRAF1 TRAF2 TRIM27	3 interacting genes: CALM2 CCDC198 UBC
Entrez ID		55195	128239
HPRD ID		12628	11051
Ensembl ID		ENSG00000100557	ENSG00000183856
Uniprot IDs		B7ZL43 E9PSE9 F5GWJ3 Q05C89 Q9NVL8	Q86VI3
PDB IDs			3ISU
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Supramolecular Fiber Organization Synaptonemal Complex Cytoplasm Organelle Organization Cytoskeleton Centrosome Cycle Cytoskeleton Organization Structural Constituent Of Skin Epidermis Thioesterase Binding Microtubule Intermediate Filament Organization Microtubule Organizing Center Organization Developmental Process Involved In Reproduction Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Centrosome Microtubule Binding Reproductive Process BHLH Transcription Factor Binding Meiotic Cell Cycle Protein Binding Microtubule-based Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding RNA Polymerase III Assembly RNA Polymerase I Assembly Tumor Necrosis Factor Receptor Binding TORC2 Complex Disassembly Meiotic Gene Conversion Negative Regulation Of Anion Channel Activity Primary Ureteric Bud Growth Myosin VI Light Chain Binding Morphogenesis Of An Epithelium Signal Transduction Involved In Regulation Of Gene Expression Intermediate Filament	Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Vesicle Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Sequestering Of Calcium Ion Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Adenylate Cyclase Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Tag Activity Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of Transporter Activity Catalytic Complex Presynaptic Cytosol Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcineurin-mediated Signaling Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Presynaptic Endocytosis Spindle Microtubule Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Cell Cycle G2/M Phase Transition Sarcomere Neural Nucleus Development Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Energy Homeostasis Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Regulation Of Monoatomic Ion Transmembrane Transporter Activity Endocytic Vesicle Membrane
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