DALRD3 and HNRNPK

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		DALRD3	HNRNPK
Name		DALR anticodon binding domain containing 3	heterogeneous nuclear ribonucleoprotein K
Structure		No pdb structure
GO Annotations	Cellular Component	None	Chromatin Podosome Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Extracellular Exosome Anchoring Junction Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Ligase Activity Arginine-tRNA Ligase Activity Protein Binding ATP Binding	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Cadherin Binding
	Biological Process	TRNA Metabolic Process TRNA Aminoacylation For Protein Translation Arginyl-tRNA Aminoacylation Gene Expression TRNA C3-cytosine Methylation	MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Processing MRNA Processing Signal Transduction RNA Splicing Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Heterochromatin Formation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Random Inactivation Of X Chromosome Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Low-density Lipoprotein Particle Clearance
Pathways		None	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events
Drugs		None	Artenimol Phenethyl Isothiocyanate
GWAS		Adiponectin levels ( 31178129 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 )	Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Lymphocyte count ( 32888494 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Triglyceride levels ( 32203549 )
Interacting Genes		14 interacting genes: BRCA1 CSNK2B CYSRT1 HNRNPK HSF2BP KHDRBS2 KRTAP12-3 KRTAP6-3 NBPF19 NOTCH2NLA PM20D2 RBM11 TK1 ZDHHC17	226 interacting genes: - ABI1 ABI2 ADRB2 ANKRD28 APBB1 APOBEC1 APOBEC3C AQP5 AURKA BCL2L13 CALCOCO2 CBLB CCAR1 CCDC187 CCDC33 CDKN1A CEBPA CEBPB CIRBP CMTM5 CNNM3 CRBN CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 DSCR9 DUX4 EIF3F ELAVL1 ETNK2 FBXL18 FBXO4 FBXO7 FBXW7 FNDC3B FOXD4L1 FOXD4L3 FOXP1 FYN GFI1B GRAP2 GRB2 GZMA GZMK HBZ HCK HMGB1 HNRNPA0 HNRNPL HNRNPLL IRGC ITK ITSN1 ITSN2 KCTD8 KHDRBS1 KHDRBS2 KHDRBS3 KLF1 LINC03040 LYN MAP2K2 MAPK10 MARCHF8 MARK4 MATR3 MDM2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MISP MRPL9 MYPOP NCK2 NEDD4 NOTO NPDC1 OGT PABPC1 PCBP1 PCBP2 PCDHB14 PCGF3 PELI2 PEX39 PGAP6 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A QKI RALY RAMAC RASAL3 RASD1 RBFOX2 RBM10 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 RNA18SN5 RNA28SN5 RNF26 RNF4 RPH3AL RTP5 SAFB SF1 SHANK3 SMAD3 SORBS3 SPG7 SRC SREK1 SRPK2 SRRT SRSF3 SUMO1 SUMO2 SYNCRIP TBP TCERG1 TCF23 TERF2IP TH TLE5 TYK2 U2AF1 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 ZFC3H1 ZNF385C ZNF408 ZNF526 ZNF575 ZNF688 ZNF792 ZNRF2P1
Entrez ID		55152	3190
HPRD ID		08549	02834
Ensembl ID		ENSG00000178149	ENSG00000165119
Uniprot IDs		Q5D0E6	B4DUQ1 P61978
PDB IDs		Not available	1J5K 1KHM 1ZZI 1ZZJ 1ZZK 7CRE 7CRU 7RJK 7RJO
GO Terms Enriched among Interactors		Identical Protein Binding Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Random Inactivation Of X Chromosome Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Poly(U) RNA Binding Regulation Of RNA Splicing Perforant Pathway To Dendrate Granule Cell Synapse Para-aminobenzoyl-glutamate Hydrolase Activity	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Extracellular Vesicle Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Angiogenesis Regulation Of RNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of Vasculature Development MRNA Processing Negative Regulation Of Locomotion Positive Regulation Of Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway