THG1L and ELMOD1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		THG1L	ELMOD1
Description		tRNA-histidine guanylyltransferase 1 like	ELMO domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Transferase Complex	Golgi Apparatus Cilium Synapse Glutamatergic Synapse
	Molecular Function	TRNA Binding Nucleotide Binding Magnesium Ion Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding TRNA Guanylyltransferase Activity Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding Metal Ion Binding	GTPase Activator Activity
	Biological Process	TRNA Modification Response To Oxidative Stress TRNA Processing Mitochondrial Fusion Protein Homotetramerization TRNA 5'-end Processing Stress-induced Mitochondrial Fusion	Intracellular Protein Localization Protein Transport Cilium Assembly
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Red cell distribution width ( 32888494)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		7 interacting genes: ELMOD1 LNX1 NTAQ1 PLEKHF2 SDCBP TERF1 UBC	1 interacting genes: THG1L
Entrez ID		54974	55531
HPRD ID		13726	10934
Ensembl ID		ENSG00000113272	ENSG00000110675
Uniprot IDs		B4E366 Q9H8R6 Q9NWX6	B4DM88 E9PLM8 Q8N336
PDB IDs		3OTB 3OTC 3OTD 3OTE 7CV1
Enriched GO Terms of Interacting Partners?		Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Shelterin Complex Assembly Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-3 Production Negative Regulation Of Immunological Synapse Formation Regulation Of Tolerance Induction Dependent Upon Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Natural Killer Cell Tolerance Induction Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Interferon-alpha Production Negative Regulation Of Defense Response To Bacterium Toll-like Receptor 7 Signaling Pathway Regulation Of Extracellular Exosome Assembly Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Ankyrin Repeat Binding Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Substrate-dependent Cell Migration, Cell Extension G-rich Strand Telomeric DNA Binding Negative Regulation Of Natural Killer Cell Activation Telomeric Loop Disassembly Negative Regulation Of T-helper 1 Type Immune Response Toll-like Receptor 9 Signaling Pathway T-circle Formation Telomere Capping Positive Regulation Of Defense Response To Bacterium	TRNA Guanylyltransferase Activity Stress-induced Mitochondrial Fusion TRNA 5'-end Processing Transferase Complex Mitochondrial Fusion Protein Homotetramerization TRNA Modification Nucleotidyltransferase Activity TRNA Binding Protein Tetramerization TRNA Processing Organelle Fusion RNA Modification Magnesium Ion Binding TRNA Metabolic Process Guanyl-nucleotide Exchange Factor Activity Protein Homooligomerization Mitochondrial Outer Membrane Mitochondrion Organization Protein Complex Oligomerization Response To Oxidative Stress GTP Binding
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