GEMIN8 and RNU2-1

Number of citations of the paper that reports this interaction (PubMedID 23221635)
111

Data Source:
BioGRID (unspecified method)

		GEMIN8	RNU2-1
Description		gem nuclear organelle associated protein 8	RNA, U2 small nuclear 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies	U2 SnRNP
	Molecular Function	Protein Binding	Pre-mRNA Branch Point Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Processing RNA Splicing	MRNA Branch Site Recognition
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS
Interacting Genes		6 interacting genes: APP DYRK1A RN7SL1 RNU1-1 RNU2-1 TSC1	10 interacting genes: DDX20 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 SMN1 SND1 STRAP
Entrez ID		54960	6066
HPRD ID		06533
Ensembl ID		ENSG00000046647	ENSG00000274585
Uniprot IDs		Q9NWZ8
PDB IDs		7BBL
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Adult Locomotory Behavior Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Actin Filament Histone H3T45 Kinase Activity Pre-mRNA Branch Point Binding MRNA Branch Site Recognition Memory T Cell Differentiation Associative Learning Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization TSC1-TSC2 Complex Adult Behavior Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cell Activation Involved In Immune Response Cellular Response To Norepinephrine Stimulus Learning Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Negative Regulation Of Heterochromatin Formation ATPase Inhibitor Activity Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Locomotory Behavior Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding	SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies Spliceosomal SnRNP Assembly Protein-RNA Complex Assembly MRNA Metabolic Process RNA Splicing MRNA Processing RNA Metabolic Process RNA Processing Nuclear Body Nucleic Acid Metabolic Process Protein-containing Complex Assembly RNA Splicing, Via Transesterification Reactions Protein-containing Complex Organization Nucleobase-containing Compound Metabolic Process Cellular Component Assembly Spliceosomal Complex Assembly Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Cytosol Nucleus RNA Binding Cytoplasm Nucleoplasm SMN-Gemin2 Complex RNAi Effector Complex Sm-like Protein Family Complex Cajal Body U2 SnRNP Binding U4atac SnRNA Binding RISC Complex Binding Dense Body U4 SnRNA Binding RNA Polymerase II Transcription Repressor Complex U1 SnRNA Binding SnRNA Binding MiRNA Catabolic Process Ribonucleoside Triphosphate Phosphatase Activity RNA 7-methylguanosine Cap Binding MRNA Binding Small Nuclear Ribonucleoprotein Complex Spliceosomal Tri-snRNP Complex Assembly DNA-templated Transcription Termination
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