ALKBH4 and MEPCE

		ALKBH4	MEPCE
Description		alkB homolog 4, lysine demethylase	methylphosphate capping enzyme
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Midbody Contractile Ring	Nucleus 7SK SnRNP Ribonucleoprotein Complex
	Molecular Function	Actin Binding Protein Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Demethylase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity Protein Demethylase Activity DNA N6-methyladenine Demethylase Activity	RNA Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity SnRNA Binding 7SK SnRNA Binding RNA 5'-gamma-phosphate Methyltransferase Activity
	Biological Process	Chromatin Organization Actomyosin Structure Organization Cleavage Furrow Ingression Demethylation Positive Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription By RNA Polymerase II RNA Methylation SnRNA Metabolic Process Methylation SnRNA Modification Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II
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Drugs
Diseases
GWAS		Morning person ( 30696823)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		19 interacting genes: BPIFA1 DTX2 EIF3C EP300 FAM168A GORASP2 HSF4 LCN2 MLLT1 MLLT3 MTMR6 NIF3L1 PSMA6 TCF4 TES TRAF4 TXNL4B WEE2-AS1 ZFHX3	2 interacting genes: ERBB2 RN7SK
Entrez ID		54784	56257
HPRD ID		07875	07889
Ensembl ID		ENSG00000160993	ENSG00000146834
Uniprot IDs		Q9NXW9	Q7L2J0
PDB IDs			5UNA 6DCB 6DCC 7SLP 7SLQ
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Cell Growth ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Demethylase Activity DNA N6-methyladenine Demethylase Activity Midbody Broad Specificity Oxidative DNA Demethylase Activity Cleavage Furrow Ingression Protein Demethylase Activity Membrane Invagination Engulfment Of Target By Autophagosome 7SK SnRNP
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