TOMM7 and TOMM40

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		TOMM7	TOMM40
Gene Name		translocase of outer mitochondrial membrane 7 homolog (yeast)	translocase of outer mitochondrial membrane 40 homolog (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Translocase Complex Integral Component Of Membrane	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Translocase Complex Integral Component Of Membrane Integral Component Of Mitochondrial Outer Membrane Pore Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity	Protein Transmembrane Transporter Activity Porin Activity
	Biological Process	Protein Targeting To Mitochondrion Protein Import Into Mitochondrial Matrix Cellular Protein Metabolic Process	Protein Targeting To Mitochondrion Ion Transport Cellular Protein Metabolic Process Protein Transmembrane Transport
Pathways		Mitochondrial protein import	Mitochondrial protein import
Drugs
Diseases
GWAS			AB1-42 ( 20932310) Age-related macular degeneration ( 22694956 23326517) Alzheimer's disease ( 22832961 18823527 19734902 19125160 20061627) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 20885792 23565137) Alzheimer's disease biomarkers ( 23562540 21123754 23419831) Brain imaging ( 20100581) C-reactive protein ( 22939635) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911) Cognitive decline ( 22054870 23207651) HDL cholesterol ( 21909109 19060911) LDL cholesterol ( 19060911) Longevity ( 21418511) Metabolic syndrome ( 22399527) Quantitative traits ( 19197348) Triglycerides ( 19060911)
Protein-Protein Interactions		3 interactors: PEX5 TOMM22 TOMM40	8 interactors: HSP90AA1 HSPA4 MTX1 PARK2 SAMM50 TOMM20 TOMM22 TOMM7
Entrez ID		54543	10452
HPRD ID		16266	16274
Ensembl ID		ENSG00000196683	ENSG00000130204
Uniprot IDs		Q75MR5 Q9P0U1	O96008
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Transmembrane Transport Establishment Of Protein Localization To Organelle Mitochondrion Organization Protein Targeting Protein Localization To Organelle Intracellular Protein Transmembrane Transport Mitochondrial Membrane Organization Protein Targeting To Mitochondrion Cytoplasmic Transport Protein Localization To Mitochondrion Intracellular Protein Transport Mitochondrial Transport Protein Import Cellular Protein Localization Protein Transport Negative Regulation Of Protein Homotetramerization Establishment Of Protein Localization Intracellular Transport Establishment Of Protein Localization To Membrane Protein Import Into Peroxisome Matrix, Translocation Transmembrane Transport Protein Import Into Peroxisome Matrix, Docking Protein Import Into Mitochondrial Outer Membrane Protein Localization Establishment Of Localization In Cell Negative Regulation Of Protein Homooligomerization Protein Localization To Membrane Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Cellular Localization Negative Regulation Of Protein Oligomerization Protein Import Into Peroxisome Matrix Organelle Organization Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Very Long-chain Fatty Acid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Membrane Organization Endoplasmic Reticulum Organization Fatty Acid Beta-oxidation Peroxisome Organization Positive Regulation Of Multicellular Organism Growth Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Transport Cerebral Cortex Cell Migration Membrane Docking	Protein Localization To Mitochondrion Protein Targeting To Mitochondrion Mitochondrial Transport Protein Import Into Mitochondrial Outer Membrane Protein Transmembrane Transport Mitochondrion Organization Protein Localization To Organelle Establishment Of Protein Localization To Organelle Intracellular Protein Transmembrane Transport Protein Targeting Cellular Protein Localization Cytoplasmic Transport Protein Import Intracellular Protein Transport Protein Localization Mitochondrial Membrane Organization Cellular Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Organelle Organization Establishment Of Localization In Cell Establishment Of Protein Localization To Membrane Protein Localization To Membrane Transport Transmembrane Transport Chaperone-mediated Protein Complex Assembly Response To Unfolded Protein Cellular Protein Metabolic Process Membrane Organization Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Protein Linear Polyubiquitination Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination
Tagcloud ?			a2m algorithm allele alzheimer amplicons apoe apoj bin1 biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion
Tagcloud (Difference) ?			a2m algorithm allele alzheimer amplicons apoe apoj bin1 biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion
Tagcloud (Intersection) ?