SHLD2 and SHLD1

Number of citations of the paper that reports this interaction (PubMedID 30254264)
36

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SHLD2	SHLD1
Description		shieldin complex subunit 2	shieldin complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Actin Cytoskeleton Site Of Double-strand Break	Chromatin Chromosome Site Of Double-strand Break
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair DNA Damage Response Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Drugs
Diseases
GWAS		Gout ( 32238385) Gout (combined type) ( 32238385) Renal underexcretion gout ( 32238385)
Interacting Genes		2 interacting genes: SHLD1 TMEM132D	4 interacting genes: MAD2L2 PRMT1 QARS1 SHLD2
Entrez ID		54537	149840
HPRD ID		09944	08681
Ensembl ID		ENSG00000122376	ENSG00000171984
Uniprot IDs		Q86V20	Q5TGA6 Q8IYI0
PDB IDs		6KTO 6WWA 7L9P
Enriched GO Terms of Interacting Partners?		Regulation Of Isotype Switching Negative Regulation Of DNA Repair Positive Regulation Of Immunoglobulin Mediated Immune Response Telomere Maintenance In Response To DNA Damage Positive Regulation Of Immunoglobulin Production Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Somatic Diversification Of Immunoglobulins Negative Regulation Of Double-strand Break Repair	Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Recombination Positive Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Stress Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA Repair Positive Regulation Of Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response Positive Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Somatic Diversification Of Immunoglobulins Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immunoglobulin Production Regulation Of DNA Metabolic Process DNA Repair Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Activation Nucleic Acid Metabolic Process Site Of Double-strand Break Telomere Maintenance GATOR1 Complex Binding DNA Damage Response, Signal Transduction Resulting In Transcription DNA Metabolic Process Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Telomere Organization Regulation Of B Cell Activation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response DNA Damage Response Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Negative Regulation Of MAPK Cascade Negative Regulation Of Metabolic Process Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains N-methyltransferase Activity
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