NLE1 and GSDMB

		NLE1	GSDMB
Description		notchless homolog 1	gasdermin B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Protein Binding	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding
	Biological Process	Mitotic Cell Cycle Somitogenesis Kidney Development Inner Cell Mass Cell Differentiation Notch Signaling Pathway Regulation Of Notch Signaling Pathway Ribosomal Large Subunit Biogenesis Negative Regulation Of Mitotic Cell Cycle Skeletal System Morphogenesis Hematopoietic Stem Cell Homeostasis Positive Regulation Of Canonical Wnt Signaling Pathway	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death
Pathways
Drugs
Diseases
GWAS			Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 23128233 28067908) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33339817) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 31672989 28314753) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 21738480 32888494)
Interacting Genes		2 interacting genes: CHRM5 EWSR1	8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1
Entrez ID		54475	55876
HPRD ID		16903	17082
Ensembl ID		ENSG00000073536	ENSG00000073605
Uniprot IDs		Q9NVX2	Q8TAX9
PDB IDs		6WAJ 8FL0 8FL2 8FL3 8FL4 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2	5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN
Enriched GO Terms of Interacting Partners?		G Protein-coupled Acetylcholine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Regulation Of Phosphatidylinositol Dephosphorylation Wide Pore Channel Activity Cytotoxic T Cell Pyroptotic Cell Death Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Regulation Of Dephosphorylation Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Transmission Of Nerve Impulse Dopamine Transport Pyroptotic Cell Death Acid Secretion Monoamine Transport Phosphatidylinositol-4-phosphate Binding Killing By Host Of Symbiont Cells Regulation Of Phospholipid Metabolic Process Biological Process Involved In Interaction With Symbiont Acetylcholine Receptor Signaling Pathway Pyroptotic Inflammatory Response Postsynaptic Signal Transduction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phosphatidylserine Binding Cajal Body	Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity
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