PPIL3 and NOP58

		PPIL3	NOP58
Description		peptidylprolyl isomerase like 3	NOP58 ribonucleoprotein
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GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome	Fibrillar Center Nucleus Nucleoplasm Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytosol Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Pre-snoRNP Complex Ribonucleoprotein Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding SnoRNA Binding ATPase Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis SnoRNA Localization
Pathways		mRNA Splicing - Major Pathway	SUMOylation of RNA binding proteins rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		10 interacting genes: CENATAC DMRTB1 PCBP1 PHC1 RPS13 SHARPIN SLU7 TAB2 TAB3 YTHDF1	8 interacting genes: ANXA1 CEBPA CSNK2A1 MAP4 OGT PTEN UBE2I WDR3
Entrez ID		53938	51602
HPRD ID		15163	11036
Ensembl ID		ENSG00000240344	ENSG00000055044
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	Q9Y2X3
PDB IDs		1XYH 2OJU 2OK3 8C6J	7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?			Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm PML Body Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sin3-type Complex Macromolecule Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Development RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Membraneless Organelle Assembly Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly SUMO Conjugating Enzyme Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly U11/U12 SnRNP Lipid Binding Positive Regulation Of Protein Metabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Negative Regulation Of Non-motile Cilium Assembly Microtubule Stabilizing Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Catalytic Step 2 Spliceosome Organelle Organization Protein Localization To Vacuole Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Negative Regulation Of Developmental Process CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Translational Initiation Protein Kinase CK2 Complex
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