PPIL3 and SPATS2L

		PPIL3	SPATS2L
Description		peptidylprolyl isomerase like 3	spermatogenesis associated serine rich 2 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity	RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)	Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Asthma (bronchodilator response) ( 22792082) Atrial fibrillation ( 30061737 29892015) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33169155) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting plasma glucose ( 32682390) FEV1 ( 30804560) Household income (MTAG) ( 31844048) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Pelvic organ prolapse ( 26545240) QT interval ( 24952745) QT interval (sulfonylurea treatment interaction) ( 27958378) Reaction time ( 27046643 29844566) Schizophrenia ( 23974872 30285260 29483656 28991256) Schizophrenia (MTAG) ( 32107650) Sleep duration ( 30846698) Systolic blood pressure ( 30224653) Urate levels in lean individuals ( 25811787) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		10 interacting genes: CENATAC DMRTB1 PCBP1 PHC1 RPS13 SHARPIN SLU7 TAB2 TAB3 YTHDF1	5 interacting genes: CSNK2A1 EEF1A1 OGT RBFOX2 ZRSR2
Entrez ID		53938	26010
HPRD ID		15163	10916
Ensembl ID		ENSG00000240344	ENSG00000196141
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	B8ZZZ7 Q9NUQ6
PDB IDs		1XYH 2OJU 2OK3 8C6J
Enriched GO Terms of Interacting Partners?			Sin3-type Complex MRNA Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Splicing Negative Regulation Of Proteolysis Involved In Protein Catabolic Process MRNA Processing Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Vacuole Regulation Of Translational Initiation RNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Protein Folding Negative Regulation Of Translation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Aggrephagy Macroautophagy Eukaryotic Translation Elongation Factor 1 Complex MRNA Splicing, Via Spliceosome Spliceosomal Complex Pre-mRNA 3'-splice Site Binding U2AF Complex RNA Processing RNA Splicing, Via Transesterification Reactions Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Nucleic Acid Metabolic Process Carbon Catabolite Regulation Of Transcription Regulation Of Chaperone-mediated Autophagy Nucleoplasm Regulation Of Transcription By Glucose Rhythmic Process Host-mediated Activation Of Viral Genome Replication Double-strand Break Repair Via Classical Nonhomologous End Joining Membraneless Organelle Assembly Host-mediated Perturbation Of Viral Genome Replication NSL Complex
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