PHKG1 and PHKG2

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		PHKG1	PHKG2
Name		phosphorylase kinase catalytic subunit gamma 1	phosphorylase kinase catalytic subunit gamma 2
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Phosphorylase Kinase Complex	Cytoplasm Cytosol Phosphorylase Kinase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylase Kinase Activity Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Tau-protein Kinase Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Signal Transduction	Glycogen Metabolic Process Glycogen Catabolic Process Generation Of Precursor Metabolites And Energy Protein Phosphorylation Signal Transduction Positive Regulation Of Glycogen Catabolic Process
Pathways		Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)	Glycogen breakdown (glycogenolysis)
Drugs		Fostamatinib	None
Diseases		None	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Macular telangiectasia type 2 ( 33654266 ) Multiple sclerosis ( 31604244 ) Plasma free amino acid levels ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: EGFR	None recorded
Interacting Genes		4 interacting genes: CALM1 CTRC MAPT PHKG2	4 interacting genes: DAPK1 MAGEA2 MAGEA2B PHKG1
Entrez ID		5260	5261
HPRD ID		01404	01405
Ensembl ID		ENSG00000164776	ENSG00000156873
Uniprot IDs		B7Z6U2 Q16816	P15735
PDB IDs		8JFK 8JFL 8XY7 8XYA 8XYB	2Y7J
GO Terms Enriched among Interactors		Regulation Of Calcium-mediated Signaling Enzyme Binding Multivesicular Body, Internal Vesicle Lumen Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Growth Membrane Raft Double-stranded DNA Binding Positive Regulation Of Growth Epidermal Growth Factor Binding ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Main Axon Regulation Of Tubulin Deacetylation Negative Regulation Of Mitochondrial Fission Negative Regulation Of Tubulin Deacetylation Lipoprotein Particle Binding Neurofibrillary Tangle Assembly Intracellular Distribution Of Mitochondria Neurofibrillary Tangle Positive Regulation Of Protein Localization To Synapse Plus-end-directed Organelle Transport Along Microtubule Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Phosphorylase Kinase Complex Phosphorylase Kinase Activity Positive Regulation Of Glycogen Catabolic Process Regulation Of Glycogen Catabolic Process Cellular Response To Growth Factor Stimulus Learning Or Memory Cellular Response To Brain-derived Neurotrophic Factor Stimulus Inclusion Body Assembly Minor Groove Of Adenine-thymine-rich DNA Binding Salivary Gland Morphogenesis	Negative Regulation Of Protein Acetylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Sumoylation Regulation Of Ubiquitin-protein Transferase Activity Cellular Senescence DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Protein Metabolic Process Signal Transduction By P53 Class Mediator Negative Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination PML Body Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding DNA-binding Transcription Factor Binding Calmodulin Binding Regulation Of Protein Ubiquitination Regulation Of NMDA Receptor Activity Phosphorylase Kinase Activity Regulation Of Post-translational Protein Modification Phosphorylase Kinase Complex Ubiquitin Protein Ligase Binding Positive Regulation Of Catalytic Activity Cellular Response To Hydroperoxide Defense Response To Tumor Cell Protein Serine Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Protein Serine/threonine Kinase Activity Signal Transduction Regulation Of Neurotransmitter Receptor Activity Intracellular Signal Transduction Syntaxin-1 Binding Response To Hydroperoxide Protein Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Regulation Of Catalytic Activity Macromolecule Metabolic Process Regulation Of Response To Tumor Cell Kinase Activity Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Receptor Activity Regulation Of Protein Modification Process Organelle Negative Regulation Of Biosynthetic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process