PHKB and PHKA2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PHKB	PHKA2
Description		phosphorylase kinase regulatory subunit beta	phosphorylase kinase regulatory subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Phosphorylase Kinase Complex Membrane	Cytoplasm Cytosol Plasma Membrane Phosphorylase Kinase Complex Membrane
	Molecular Function	Protein Binding Calmodulin Binding	Phosphorylase Kinase Activity Protein Binding Calmodulin Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy	Carbohydrate Metabolic Process Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Protein Modification Process
Pathways		Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)	Glycogen breakdown (glycogenolysis)
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Interacting Genes		5 interacting genes: ADISSP CALM1 CAMK2B HNRNPC PHKA2	4 interacting genes: PHKB RAF1 SMAD9 UROD
Entrez ID		5257	5256
HPRD ID		01407	02380
Ensembl ID		ENSG00000102893	ENSG00000044446
Uniprot IDs		Q93100	P46019
PDB IDs		8JFK 8JFL 8XYA
Enriched GO Terms of Interacting Partners?			Heteromeric SMAD Protein Complex SMAD Protein Complex Phosphorylase Kinase Complex Insulin Secretion Involved In Cellular Response To Glucose Stimulus Adenylate Cyclase Activator Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Death-inducing Signaling Complex Assembly Heme O Biosynthetic Process Porphyrin-containing Compound Catabolic Process Uroporphyrinogen Decarboxylase Activity Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme B Biosynthetic Process Protoporphyrinogen IX Metabolic Process Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway SMAD Protein Signal Transduction Intracellular Chemical Homeostasis I-SMAD Binding Response To Muscle Stretch Type B Pancreatic Cell Proliferation Schwann Cell Development ERBB2 Signaling Pathway MAP Kinase Kinase Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Face Development Pseudopodium Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Carboxy-lyase Activity Cellular Response To BMP Stimulus Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Thyroid Gland Development Cellular Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Heme Metabolic Process
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