C9orf78 and PTGES2

		C9orf78	PTGES2
Description		chromosome 9 open reading frame 78	prostaglandin E synthase 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Spliceosomal Complex Chromosome Cytosol	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Binding U5 SnRNA Binding	DNA Binding Protein Binding Lyase Activity Isomerase Activity Heme Binding 12-hydroxyheptadecatrienoic Acid Synthase Activity Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Chromosome Segregation RNA Splicing MRNA Cis Splicing, Via Spliceosome Regulation Of Homologous Chromosome Segregation	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Positive Regulation Of DNA-templated Transcription Prostanoid Biosynthetic Process Secretion
Pathways		mRNA Splicing - Major Pathway	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Neutrophil degranulation
Drugs
Diseases			Penile cancer
GWAS			Body mass index ( 26426971)
Interacting Genes		6 interacting genes: APP FCHSD2 MAPK11 SMURF1 SUPT5H TAB1	6 interacting genes: ADRB2 CEBPB CFAP141 EXOSC10 HSPA13 PTGFR
Entrez ID		51759	80142
HPRD ID		10803	07458
Ensembl ID		ENSG00000136819	ENSG00000148334
Uniprot IDs		Q9NZ63	A0A7I2V5X6 A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7
PDB IDs		7OS2 8C6J 9FMD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Clathrin-coated Pit Stereocilium Shaft Engulfment Of Target By Autophagosome Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Interleukin-1 Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Positive Regulation Of Cytokine Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process DSIF Complex 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Regulation Of Growth Recycling Endosome Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Supramolecular Fiber Organization Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway	Regulation Of Sodium-dependent Phosphate Transport Regulation Of Phosphate Transport Brown Fat Cell Differentiation Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential Photoreactive Repair Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Prostaglandin F Receptor Activity Beta2-adrenergic Receptor Activity Granuloma Formation C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis T-helper 1 Cell Activation Kinase Binding CHOP-C/EBP Complex Positive Regulation Of Sodium-dependent Phosphate Transport Cry-Per Complex Regulation Of Homologous Chromosome Segregation U5 SnRNA Binding Norepinephrine Binding Negative Regulation Of Glucocorticoid Secretion Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Response To Psychosocial Stress Fat Cell Differentiation Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway SnRNA Catabolic Process CUT Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagosome Maturation Regulation Of Cold-induced Thermogenesis Heat Generation Nucleic Acid Metabolic Process Hepatocyte Proliferation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Blue Light Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway
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