PDYN and PIGS

		PDYN	PIGS
Description		prodynorphin	phosphatidylinositol glycan anchor biosynthesis class S
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Dendrite Neuronal Cell Body Axon Terminus Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex
	Molecular Function	Opioid Peptide Activity Protein Binding Opioid Receptor Binding	Protein Binding
	Biological Process	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception	GPI Anchor Biosynthetic Process Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events	Attachment of GPI anchor to uPAR
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Aortic root size ( 21223598) Immune response to measles-mumps-rubella vaccine ( 24811271) Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels ( 23823483) Platelet count ( 29403010)
Interacting Genes		2 interacting genes: APP NRDC	14 interacting genes: CPEB2 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP6-3 KRTAP9-2 NBPF19 NOTCH2NLA TRIP6
Entrez ID		5173	94005
HPRD ID		08838	15135
Ensembl ID		ENSG00000101327	ENSG00000087111
Uniprot IDs		P01213	Q8NBL9 Q96IR5 Q96S52
PDB IDs		2N2F 7Y1F 8F7W 8VJU 8VJV	7W72 7WLD 8IMX 8IMY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Membrane Protein Ectodomain Proteolysis Dendrite Membrane Regulation Of Membrane Protein Ectodomain Proteolysis Dendrite Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Nervous System Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Epidermal Growth Factor Binding GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Sarcoglycan Complex Attachment Of GPI Anchor To Protein Cell Projection Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity	Intermediate Filament Keratin Filament
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