PDR and CYP4F2

Number of citations of the paper that reports this interaction (PMID 9618440)
28

Data Source:
BioGRID (enzymatic study, biochemical, biochemical)

		PDR	CYP4F2
Gene Name		pigment disorder, reticulate	cytochrome P450, family 4, subfamily F, polypeptide 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Endoplasmic Reticulum Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function		Iron Ion Binding Protein Binding Arachidonic Acid Epoxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Leukotriene-B4 20-monooxygenase Activity Arachidonic Acid Omega-hydroxylase Activity Alpha-tocopherol Omega-hydroxylase Activity Tocotrienol Omega-hydroxylase Activity
	Biological Process		Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Icosanoid Metabolic Process Leukotriene Metabolic Process Xenobiotic Metabolic Process Blood Coagulation Regulation Of Blood Pressure Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Blood Coagulation Negative Regulation Of Icosanoid Secretion Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Vitamin K Biosynthetic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Small Molecule Metabolic Process Sodium Ion Homeostasis Oxidation-reduction Process Omega-hydroxylase P450 Pathway
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Miscellaneous substrates Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Fatty acids Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS			Acenocoumarol maintenance dosage ( 19578179) Metabolite levels ( 23281178) Response to Vitamin E supplementation ( 22437554) Vitamin E levels ( 21729881) Warfarin maintenance dose ( 20833655 19300499)
Protein-Protein Interactions		1 interactors: CYP4F2	2 interactors: CYB5A PDR
Entrez ID		5171	8529
HPRD ID			05112
Ensembl ID			ENSG00000186115
Uniprot IDs			P78329
PDB IDs
Enriched GO Terms of Interacting Partners?		Menaquinone Catabolic Process Vitamin K Catabolic Process Phylloquinone Catabolic Process Vitamin K Biosynthetic Process Pressure Natriuresis Negative Regulation Of Icosanoid Secretion Vitamin E Metabolic Process Leukotriene B4 Catabolic Process Vitamin K Metabolic Process Ketone Catabolic Process Long-chain Fatty Acid Catabolic Process Omega-hydroxylase P450 Pathway Epoxygenase P450 Pathway Positive Regulation Of Icosanoid Secretion Negative Regulation Of Lipid Transport Sodium Ion Homeostasis Positive Regulation Of Fatty Acid Transport Renal Water Homeostasis Very Long-chain Fatty Acid Metabolic Process Regulation Of Fatty Acid Transport Leukotriene Metabolic Process Quinone Metabolic Process Drug Metabolic Process Multicellular Organismal Water Homeostasis Negative Regulation Of Blood Coagulation Positive Regulation Of Lipid Transport Negative Regulation Of Coagulation Water Homeostasis Arachidonic Acid Metabolic Process Negative Regulation Of Wound Healing Fatty Acid Catabolic Process Cellular Ketone Metabolic Process Regulation Of Lipid Transport Negative Regulation Of Ion Transport Icosanoid Metabolic Process Regulation Of Systemic Arterial Blood Pressure Renal System Process Regulation Of Blood Coagulation Unsaturated Fatty Acid Metabolic Process Vitamin Metabolic Process Long-chain Fatty Acid Metabolic Process Regulation Of Wound Healing Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Regulation Of Anion Transport Response To Xenobiotic Stimulus Cellular Lipid Catabolic Process Coenzyme Biosynthetic Process Regulation Of Blood Pressure Negative Regulation Of Secretion	L-ascorbic Acid Metabolic Process Response To Cadmium Ion Water-soluble Vitamin Metabolic Process Vitamin Metabolic Process Hydrogen Ion Transmembrane Transport Proton Transport Monosaccharide Metabolic Process
Tagcloud ?		absolutely ap arf cargo carrier casein cathepsin cd clathrin coat coated determinant di endocytic endocytosis eseer golgi gtpase hllpm leucine mannose mphs mpr mprs property recruiting segregated sorting vesicles	11q23 19p13 2p12 5q22 8q24 a4 a5 apoa1 c3 cdo1 circulating clinicaltrials col22a1 consortium ctnaa2 descent determinants framingham gov gwa interindividual nct00005121 nct00005487 phylloquinone unexplained verify vitamin warfarin weights
Tagcloud (Difference) ?		absolutely ap arf cargo carrier casein cathepsin cd clathrin coat coated determinant di endocytic endocytosis eseer golgi gtpase hllpm leucine mannose mphs mpr mprs property recruiting segregated sorting vesicles	11q23 19p13 2p12 5q22 8q24 a4 a5 apoa1 c3 cdo1 circulating clinicaltrials col22a1 consortium ctnaa2 descent determinants framingham gov gwa interindividual nct00005121 nct00005487 phylloquinone unexplained verify vitamin warfarin weights
Tagcloud (Intersection) ?